Auvergne-Rhône-Alpes-Limousin Research Database for Still's Diseases in Children and Adults

Status: Recruiting
Location: See all (16) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Adult-Onset Still's disease is a polygenic autoinflammatory disease of unknown etiology. The autoinflammatory character individualizes it from autoimmune autoantibody diseases. Clinically, it results in the classic triad associating hectic fever, evanescent rash and arthritis. Although it is benign in the vast majority of cases, life-threatening complications can occur. By definition, the disease affects adults over 16 years of age, however most experts now agree that the adult form and the pediatric form belong to a pathological continuum: Still's disease. In the absence of a specific biomarker, the diagnosis is still based on clinical and biological criteria, after the exclusion of differential diagnoses. Classically, three evolutionary profiles of Adult-Onset Still's disease are individualized, depending on the evolution of symptoms over time: * a monocyclic systemic form (30% of cases) characterized by clear systemic symptoms and in the foreground compared to the articular signs. This form evolves over several weeks to several months (on average 9 months), without exceeding a year. By definition, there is no recurrence; * a polycyclic systemic form (30% of cases) defined by the occurrence of at least two systemic or joint episodes, separated by clinical remission intervals greater than two months, or even several years. The symptoms of relapses are not always the same as the initial symptoms. The number and severity of relapses is unpredictable and varies widely from patient to patient, but symptoms tend to become less severe over time. * a chronic form, with predominant joint involvement (40%), resembling seronegative rheumatoid arthritis. Systemic signs are present during the first outbreaks of the disease. Subsequently, rheumatoid arthritis evolves on its own and one can see joint destruction or conversely ankylosing developments such as the classic bilateral, non-erosive fusing carpitis. There are reasons to believe that the evolving profile of patients has changed since the emergence and generalization of biotherapies. Furthermore, no prognostic factor for the progression of Adult-Onset Still's disease has been found so far. The differences between pediatric and adult forms need to be confirmed and becoming pediatric forms in adulthood is poorly described. The objective of this study is to set up a regional research database (Auvergne-Rhône-Alpes-Limousin) in order to describe the characteristics, treatment and evolution of patients with Still's disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Healthy Volunteers: f
View:

• children and adult diagnosed with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital

Locations
Other Locations
France
Centre Hospitalier d'Annecy
RECRUITING
Annecy
Centre Hospitalier de Bourg en Bresse
RECRUITING
Bourg-en-bresse
Centre Hospitalier Bourgoin Jallieu
RECRUITING
Bourgoin
Centre Hospitalier de Châlon sur Saône
RECRUITING
Châlon Sur Saône
Centre Hospitalier de Chambéry
RECRUITING
Chambéry
Centre Hospitalier Alpes-Léman (CHAL)
RECRUITING
Contamine-sur-arve
Centre Hospitalier du puy en velay
RECRUITING
Le Puy-en-velay
Centre Hospitalier de Limoges
RECRUITING
Limoges
Hôpital de la Croix Rousse
RECRUITING
Lyon
Hopital Saint Luc Saint Joseph
RECRUITING
Lyon
Hospices Civils de Lyon - Edouard Herriot
RECRUITING
Lyon
Centre Hospitalier de Montélimar
RECRUITING
Montélimar
Centre Hospitalier de Valence
RECRUITING
Valence
Centre Hospitalier Vienne
RECRUITING
Vienne
Centre Hospitalier de Villefranche
RECRUITING
Villefranche-sur-saône
Médipôle de Villeurbanne
RECRUITING
Villeurbanne
Contact Information
Primary
Yvan Jamilloux, Dr
yvan.jamilloux@chu-lyon.fr
+33426732636
Time Frame
Start Date: 2020-02-01
Estimated Completion Date: 2025-12
Participants
Target number of participants: 400
Treatments
children and adult diagnosed with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
children and adult with Still's disease in Auvergne-Rhône-Alpes-Limousin hospital
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov