The Clinical Features and Pregnancy Outcomes of Patients With Rheumatoid Arthritis :a Prospective Cohort Study
This study includes RA patients in pregnancy, who are using different treatment regimens，including prednisone, hydroxychloroquine, and/or TNF inhibitors. The maternal disease activity, pregnancy outcomes, maternal and fetal safety are assessing during the trimester of pregnancy. The effects of different therapies and risk factors for adverse pregnancy outcomes will be analysis.
⁃ \- 1.Age between 20 and 45 years old.
• Diagnosis of RA: Approved by the American College of Rheumatology and the European League Against Rheumatism in 2010.
⁃ Involved joints 1 large joint (0 points) 2-10 large joints (1 point) 1-3 small joints (with or without large joints) (2 points) 4-10 small joints (with or without large joints) (3 points) more than 10 small joints (at least one small joint) (5 points)
⁃ Serological indicators RF and ACPA negative (0 points) RF and ACPA, at least one of which is low titer positive. (2 points) RF and ACPA with at least one high titer positive (3 points)
⁃ Acute chronotropic reactants Both CRP and ESR normal (0 points) Abnormal CRP or ESR (1 point)
⁃ Duration of synovitis \<6 weeks (0 points)
⁃ ≥6 weeks (1 point)
• Voluntary participation in this study, willingness to administer medication and follow up according to the treatment plan, and signing of an informed consent form.