Research on the Application of 99mTc-TCR-FAPI SPECT Imaging in Rheumatoid Arthritis
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study proposes to evaluate 99mTc-CTR-FAPI SPECT imaging as a cost-effective, low-radiation, and widely accessible alternative to 68Ga-FAPI PET/CT for assessing synovial lesions in RA patients, aiming to validate its diagnostic consistency with both PET/CT and physical examinations while correlating imaging findings with clinical disease activity metrics to establish a practical tool for long-term RA monitoring.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age: 18-75 years old;
• Meet the classification criteria for rheumatoid arthritis of the American College of Rheumatology/European Union for Rheumatology in 2010;
• The highest disease activity in clinical practice (CDAI or SDAI score
Locations
Other Locations
China
Peking Union Medical College Hospital
RECRUITING
Beijing
Contact Information
Primary
Yaping Luo, MD
luoyaping@live.com
86-010-69154716
Time Frame
Start Date: 2025-05-10
Estimated Completion Date: 2028-04-28
Participants
Target number of participants: 20
Treatments
Experimental: 68Ga-FAPI PET/CT& 99mTc-CTR-FAPI SPECT
All enrolled patients will undergo one 99mTc-CTR-FAPI SPECT scan and one 68Ga-FAPI PET/CT scan within a 1-week interval.
Related Therapeutic Areas
Sponsors
Leads: Luo Yaping
Collaborators: Peking Union Medical College Hospital