SAPHO Syndrome
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SAPHO Syndrome Overview

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Learn About SAPHO Syndrome

What is the definition of SAPHO Syndrome?
SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). The cause of SAPHO syndrome is unknown..
What are the alternative names for SAPHO Syndrome?
  • SAPHO syndrome
  • Acquired hyperostosis syndrome
  • Synovitis acne pustulosis hyperostosis osteitis
  • Synovitis, Acne, Pustlosis, Hyperostosis, and Osteomyelitis
Who are the top SAPHO Syndrome Local Doctors?
Elite in SAPHO Syndrome
Daniel Wendling
Elite in SAPHO Syndrome
Daniel Wendling

CHU Gabriel Montpied

Clermont-ferrand, FR 

Daniel Wendling practices practicing medicine in Clermont-ferrand, France. Mr. Wendling is rated as an Elite expert by MediFind in the treatment of SAPHO Syndrome. He is also highly rated in 29 other conditions, according to our data. His clinical expertise encompasses Arthritis, Ankylosing Spondylitis, Rhizomelic Pseudopolyarthritis, and Polymyalgia Rheumatica.

Elite in SAPHO Syndrome
Chen K. Li
Elite in SAPHO Syndrome
Chen K. Li
Peking Union Medical College Hospital, Peking Union Medical College, 
Beijing, CN 

Chen Li practices practicing medicine in Beijing, China. Li is rated as an Elite expert by MediFind in the treatment of SAPHO Syndrome. They are also highly rated in 10 other conditions, according to our data. Their clinical expertise encompasses SAPHO Syndrome, Acne, Synovitis, and Pustules.

 
 
 
 
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Elite in SAPHO Syndrome
Yihan Cao
Elite in SAPHO Syndrome
Yihan Cao

Peking Union Medical College Hospital, Peking Union Medical College And Chinese Academy Of Medical Sciences

Beijing, CN 

Yihan Cao practices practicing medicine in Beijing, China. Cao is rated as an Elite expert by MediFind in the treatment of SAPHO Syndrome. They are also highly rated in 4 other conditions, according to our data. Their clinical expertise encompasses SAPHO Syndrome, Synovitis, Acne, and Osteomyelitis in Children.

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What are the latest SAPHO Syndrome Clinical Trials?
A Multicenter, Randomized, Double-blind Clinical Trial Evaluating the Efficacy and Safety of Etanercept Versus Placebo in the Treatment of Patients With SAPHO Syndrome
A Multicenter, Randomized, Double-blind Clinical Trial Evaluating the Efficacy and Safety of Etanercept Versus Placebo in the Treatment of Patients With SAPHO Syndrome
Enrollment Status: Recruiting
Publish Date: April 13, 2026
Intervention Type: Drug
Study Phase: Phase 2/Phase 3

Summary: The study includes adult patients with SAPHO syndrome (ORPHA: 793), meeting the modified classification criteria according to Kahn (2003), with the ineffectiveness of standard treatment (patient's global assessment of the disease on the VAS scale greater than or equal to 4 cm with accompanying pain on the VAS scale greater than or equal to 4 cm) treated with non-steroidal anti-inflammatory drugs i...

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Study of the Pathophysiological Mechanisms Involved in the SAPHO Syndrome: Genetic Component and Immune Response
Study of the Pathophysiological Mechanisms Involved in the SAPHO Syndrome: Genetic Component and Immune Response
Enrollment Status: Recruiting
Publish Date: December 24, 2025
Intervention Type: Other

Summary: SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a chronic inflammatory rheumatism associating bone or joint lesions and dermatological manifestations dominated by severe acne and palmar and palmoplantar pustulosis. Prevalence of SAPHO syndrome is estimated at 1/50000 in France, but this figure is probably underestimated due to frequent misdiagnosis. Osteoarticular manife...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center