Combination of NMDA-enhancing and Anti-inflammatory Treatments for Ultra-resistant Schizophrenia
Previous study found that some NMDA-enhancing agent was able to augment efficacy of clozapine for clinical symptoms but not cognitive function in the treatment of ultra-resistant schizophrenia. In addition, several drugs with anti-inflammatory properties have been tested in clinical trials for the treatment of schizophrenia. Whether a drug with anti-inflammatory property can strengthen the efficacy of an NMDA-enhancer (NMDAE) in the treatment of ultra-resistant schizophrenia remains unknown.
• Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia
• Are treatment-resistant to standard treatments of at least two specific antipsychotics before clozapine treatment
• Are receiving adequate trials of clozapine for more than 12 weeks but without satisfactory response
• PANSS total score ≥ 70; SANS total score ≥ 40
• Have sufficient education to communicate effectively and are capable of completing the assessments of the study
• Agree to participate in the study and provide informed consent