Multiomic Diagnostics in Child and Adolescent Psychosis

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Genetic
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of psychosis that may inform new treatment for future patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Maximum Age: 17
Healthy Volunteers: f
View:

⁃ Individual in whom one of the following criteria is met:

• Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis

• OR

• Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.

Locations
United States
California
Rady Children's Hospital San Diego
RECRUITING
San Diego
Contact Information
Primary
Aaron Besterman, MD
abesterman@health.ucsd.edu
858-576-1700
Backup
Corrine Blucher, BS
cblucher@rchsd.org
858-576-1700
Time Frame
Start Date: 2022-10-10
Estimated Completion Date: 2026-08
Participants
Target number of participants: 15
Treatments
Experimental: Enrollees - WGS
These participants will be subject to whole genome sequencing and Phage ImmunoPrecipiation sequencing (PhIP-Seq) to identify genetic changes and novel antibodies associated with psychosis.
Related Therapeutic Areas
Sponsors
Leads: Rady Pediatric Genomics & Systems Medicine Institute

This content was sourced from clinicaltrials.gov