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Establishing a Clinical Database and Biobank for Schizophrenia:A Cohort Study

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

This is a multicenter study conducted in collaboration with Central South University, The First Affiliated Hospital of Zhengzhou University, Nanjing Brain Hospital of Nanjing Medical University, and Anhui Mental Health Center. The project intends to employ standardized diagnostic criteria and clinical assessment procedures to establish a comprehensive cohort of patients with schizophrenia, encompassing all age groups and disease stages, with follow-up periods exceeding one year. The goal is to create an internationally high-standard clinical cohort database and biobank for schizophrenia. Through a multidimensional assessment framework, the project aims to further investigate the etiology of schizophrenia, patterns of disease progression, and clinical outcomes. By periodically capturing dynamic information on risk and preventive factors, the project aims to achieve early diagnosis, early treatment, and improved prognosis for patients. Additionally, it seeks to explore potential biomarkers within the realm of precision medicine that can predict treatment efficacy, providing viable tools for precision healthcare and clinical decision-making in the field of schizophrenia.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• 1.Clinical diagnosis of schizophrenia according to ICD-11.

• 2.Confirmation of the diagnosis of schizophrenia using the SCID-5-RV (DSM-5 Structured Clinical Interview for DSM-5 Disorders - Research Version).

Locations
Other Locations
China
Mental Health Institute of Second Xiangya Hospital,CSU
RECRUITING
Changsha
Anhui Mental Health Center
ACTIVE_NOT_RECRUITING
Hefei
Nanjing Brain Hospital, Nanjing Medical University
ACTIVE_NOT_RECRUITING
Nanjing
The First Affiliated Hospital of Zhengzhou University
ACTIVE_NOT_RECRUITING
Zhengzhou
Contact Information
Primary
Renrong Wu, M.D., Ph.D.
wurenrong2013@163.com
15874179855
Backup
Hui Tang, M.D.
tanghuicsu@163.com
15802686545
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 2000
Treatments
Individuals with schizophrenia
Inclusion Criteria:~* 1.Clinical diagnosis of schizophrenia according to ICD-11.~* 2.Confirmation of the diagnosis of schizophrenia using the SCID-5-RV (DSM-5 Structured Clinical Interview for DSM-5 Disorders - Research Version).~Exclusion criteria:~* 1.Clinical diagnosis or SCID-5-RV assessment confirming neurodevelopmental disorders, bipolar and related disorders, substance use disorders (excluding alcohol and tobacco).~* 2.Presence of severe or acute physical illnesses, including traumatic brain injury, intracranial space-occupying or infectious diseases, acute cardiovascular diseases, acute respiratory system diseases, acute hematological disorders, etc.~* 3.Presence of clearly defined genetic diseases, including tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, Klinefelter syndrome (47,XXY), etc.
Healthy volunteers
* Inclusion Criteria:~ 1. Ages 13-60 years old.~ 2. Clinical diagnosis not meeting ICD-11 criteria for schizophrenia.~ 3. Diagnosis not meeting schizophrenia criteria confirmed using SCID-5-RV (DSM-5 Structured Clinical Interview for DSM-5 Disorders - Research Version).~* Exclusion criteria are the same as for the schizophrenia patient group.
Related Therapeutic Areas
Sponsors
Collaborators: The First Affiliated Hospital of Zhengzhou University, The Affiliated Brain Hospital of Nanjing Medical University, Anhui Mental Health Center
Leads: Central South University

This content was sourced from clinicaltrials.gov