Dual Modulation of Sigma-1 and NMDA Receptors in the Treatment of Schizophrenia
sigma-1 receptor (S1R) agonistic property have been tested in clinical trials for the treatment of schizophrenia. In addition, previous studies found that some NMDA receptor (NMDAR)-enhancing agents were able to improve clinical symptoms of patients with chronic schizophrenia. Whether combined treatment of an S1R agonist and an NMDA-enhancing agent can be better than an S1R agonist alone deserves study.
• Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia
• Are resistant to adequate treatments of at least two antipsychotics (excluding clozapine)
• Remain symptomatic but without clinically significant fluctuation, while their antipsychotic doses are unchanged for at least 3 months and will be maintained during the period of the 8-week trial
• PANSS total score \>70
• Hamilton Depression Rating Scale-17 items (HAMD) \<7
• Are physically healthy and laboratory assessments (including blood routine, biochemical tests) are clinically insignificant.
• Have sufficient education to communicate effectively and are capable of completing the assessments of the study.
• Agree to participate in the study and provide informed consent