HYEEG Discourse in Psychosis: A Neurobehavioural Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify measurable markers of disorganized communication and link them to clinical symptoms and social functioning. Key Research Questions: How do neural and behavioural synchrony contribute to social impairments in schizophrenia? What roles do interbrain synchrony, motor imitation, reaction time, and verbal coherence play in disorganized communication? Participants will: 1. Engage in structured and semi-structured real-time social interactions while undergoing dual-brain electroencephalogram (EEG) hyperscanning to measure neural and behavioural activity. 2. Perform nonverbal tasks such as motor imitation and reaction time assessments to investigate coordination and behavioural synchrony patterns. 3. Participate in a clinical interview that evaluates verbal production, thought coherence, and speech organization. By combining these assessments, the study aims to advance our understanding of how social and communication impairments manifest in schizophrenia. The findings will contribute to developing improved diagnostic tools and targeted interventions, ultimately supporting patients in achieving better social functioning and quality of life.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• English or French-speaking participants (as dyads matched for language preference).

• Ages 18-60 years.

• Patients meeting the operational criteria for schizophrenia or schizoaffective illness as previously diagnosed by their treating psychiatrist, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria (Zipursky et al., 2020).

• Patients with less than 5 years of illness onset, based on the time of starting treatment with antipsychotic medication.

Locations
Other Locations
Canada
Douglas Mental Health University Institute
RECRUITING
Montreal
Contact Information
Primary
Emmanuel Olarewaju, PhD Candidate
emmanuel.olarewaju@mail.mcgill.ca
5147616131
Backup
Lena Palaniyappan, MD, PhD
lena.palaniyappan@mcgill.ca
5147616131
Time Frame
Start Date: 2024-01-16
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 110
Treatments
Healthy controls
1. English or French-speaking participants (as dyads matched for language preference).~2. Ages 18-60 years.~3. No diagnosis of schizophrenia or schizoaffective illness based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria.
Patients
1. English or French-speaking participants (as dyads matched for language preference).~2. Ages 18-60 years.~3. Patients meeting the operational criteria for schizophrenia or schizoaffective illness as previously diagnosed by their treating psychiatrist, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria.~4. Patients with less than 5 years of illness onset, based on the time of starting treatment with antipsychotic medication.
Related Therapeutic Areas
Sponsors
Leads: Douglas Mental Health University Institute

This content was sourced from clinicaltrials.gov