Condition 101 About Scleredema

What is the definition of Scleredema?

Scleredema is a form of cutaneous mucinosis, a diverse group of rare skin conditions that are characterized by an accumulation of mucin (a jelly-like complex carbohydrate substance) in the skin. Signs and symptoms of this condition include hardening and thickening of the skin which may restrict movement. Skin in affected areas may be red or brown and often has an 'orange-skin' appearance. There are three forms of the condition which vary by disease course and long term outlook (prognosis). Although the underlying cause is currently unknown, each form is associated with a different condition: infection (type 1), blood abnormalities (type 2), and diabetes (type 3). In some cases, scleredema resolves spontaneously on its own, while in other affected people, the condition persists for long periods of time. Due to the rarity of the condition, there is no standard treatment.

What are the alternative names for Scleredema?

  • Scleredema adultorum
  • Scleredema adultorum of Buschke
  • Scleredema diabeticorum
  • Scleredema diabeticorum of Buschke
  • Buschke's scleredema

Latest Advances On Scleredema

  • Condition: Congenital Diaphragmatic Hernia (CDH) in Neonates
  • Journal: Journal of cardiothoracic surgery
  • Treatment Used: Thoracoscopic vs. Open Surgery
  • Number of Patients: 26
  • Published —
This study compared thoracoscopic versus open surgery of congenital diaphragmatic hernia in neonates.
  • Condition: Neonatal hypoxic-ischemic encephalopathy
  • Journal: Zhonghua wei zhong bing ji jiu yi xue
  • Treatment Used: Selective brain hypothermia therapy
  • Number of Patients: 42
  • Published —
This study evaluated the efficacy and safety of selective brain hypothermia in the treatment of neonates with neonatal hypoxic-ischemic encephalopathy.