Role of Innate T Cells in Physiopathology of Systemic Sclerosis
Innate T cells (ITC) are decreased in systemic sclerosis (SS) and an early lymphocyte innateness has been reported. In the other part, ITC are implicated on inflammatory process, including the IL-33/ST2 axis, which is also involved in ScS endotheliopathy. Data are however scarce and physiopathological mechanisms have not been assessed to date. The investigators hypothesize a global lymphocyte innateness in SSc, linked to a chronic ITC stimulation by innate signals leading to ITC exhaustion, and their potential role in endotheliopathy and fibroblast activation in SSc.
• SSc according to the 2013 ACR/EULAR 2013 criteria (or the 2001 Leroy's criteria for early SSc)
• Patients with others connective tissue disease:
‣ Systemic erythematosus lupus (SLE) according to the 2019 ACR/EULAR criteria
⁃ Primary Sjögren syndrome (pSS) according to the 2016 ACR/EULAR criteria
⁃ Rheumatoid arthritis according to the 2010 ACR/EULAR criteria
⁃ Idiopathic inflammatory myopathy (IIM) according to the 2017 ACR/EULAR criteria
• Healthy subjects from general population without known autoimmune disease or connective tissue disease
• ≥18 years-old