Learn About Sea-Blue Histiocytosis

What is the definition of Sea-Blue Histiocytosis?
Sea-blue histiocytosis, also known as inherited lipemic splenomegaly, is an extremely rare condition characterized by elevated triglyceride levels (hypertriglyceridemia) and an enlarged spleen (splenomegaly). The disorder is so named because certain white blood cells, known as histiocytes, appear bright blue when stained and viewed under the microscope. Additional signs and symptoms may include a low platelet count (thrombocytopenia), liver function abnormalities, and heart disease. It is one of a group of related fat (lipid) disorders caused by certain changes in the APOE gene. The genetic change associated with this condition is inherited in an autosomal dominant manner though other factors, such as a patient's gender, the patient's lipid levels, and the genetic makeup of the other APOE gene may play a role in how the condition is expressed. There are currently no formal treatment guidelines. Management may involve the coordinated care of several different specialists including cardiologists, gastroenterologists, and hematologists. Patients with splenomegaly should be careful to avoid contact sports. Removal of the spleen (splenectomy) has been reported to make the condition worse. Sea-blue histiocytes can also be a secondary finding associated with a wide range of disorders, including myelodysplastic syndromes, lymphomas, chronic myelogenous leukemia, idiopathic thrombocytopenic purpura, Niemann-Pick disease, and Norum disease. In these cases, treatment depends on the underlying disorder.
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What are the alternative names for Sea-Blue Histiocytosis?
  • Histiocytosis, sea-blue
  • Sea-Blue histiocyte disease
  • Inherited Lipemic Splenomegaly
Who are the top Sea-Blue Histiocytosis Local Doctors?
Distinguished
Highly rated in
39
conditions
Neurology

Memorial Sloan Kettering Cancer Center

New York, NY 

Eli Diamond is a Neurologist in New York, New York. Dr. Diamond has been practicing medicine for over 15 years and is rated as a Distinguished doctor by MediFind in the treatment of Sea-Blue Histiocytosis. He is also highly rated in 39 other conditions, according to our data. His top areas of expertise are Erdheim-Chester Disease, Non-Langerhans-Cell Histiocytosis, Histiocytosis, and Reticulohistiocytoma. He is board certified in Neurology and licensed to treat patients in New York. Dr. Diamond is currently accepting new patients.

Distinguished
Highly rated in
69
conditions
Hematology Oncology
Oncology

Harrison HealthPartners Hematology & Oncology Poulsbo

Poulsbo, WA 

Dennis Willerford is a Hematologist Oncology specialist and an Oncologist in Poulsbo, Washington. Dr. Willerford has been practicing medicine for over 37 years and is rated as a Distinguished doctor by MediFind in the treatment of Sea-Blue Histiocytosis. He is also highly rated in 69 other conditions, according to our data. His top areas of expertise are Reticulohistiocytoma, Multicentric Reticulohistiocytosis, Rosai-Dorfman Disease, and Sea-Blue Histiocytosis. He is board certified in Medical Oncology and licensed to treat patients in Washington. Dr. Willerford is currently accepting new patients.

 
 
 
 
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Distinguished
Highly rated in
47
conditions
Hematology

USC Norris Comprehensive Cancer Center & Hospital

Los Angeles, CA 

Ilene Weitz is a Hematologist in Los Angeles, California. Dr. Weitz has been practicing medicine for over 46 years and is rated as a Distinguished doctor by MediFind in the treatment of Sea-Blue Histiocytosis. She is also highly rated in 47 other conditions, according to our data. Her top areas of expertise are Hemolysis, Paroxysmal Nocturnal Hemoglobinuria, Paroxysmal Cold Hemoglobinuria, and Hemolytic Anemia. She is board certified in Hematology and Internal Medicine and licensed to treat patients in California. Dr. Weitz is currently accepting new patients.

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What are the Latest Advances for Sea-Blue Histiocytosis?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.