Secondary systemic amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits.

Secondary means it occurs because of another disease or situation. For example, this condition usually occurs due to long-term (chronic) infection or inflammation. In contrast, primary amyloidosis is a primary hematological disorder that results in deposition of abnormal amyloid proteins in different organs such as the heart and kidney.

Systemic means that the disease affects the entire body.

Amyloidosis - secondary systemic; AA amyloidosis

The exact cause of secondary systemic amyloidosis is unknown. You are more likely to develop secondary systemic amyloidosis if you have a long-term infection or inflammation.

This condition may occur with:

• Ankylosing spondylitis -- a form of arthritis that mostly affects the bones and joints in the spine
• Bronchiectasis -- a disease in which the large airways in the lungs are damaged by chronic infection
• Chronic osteomyelitis -- a long-standing bone infection
• Cystic fibrosis -- a genetic disease that causes thick, sticky mucus to build up in the lungs, digestive tract, and other areas of the body, leading to chronic infection of the lungs
• Familial Mediterranean fever -- an inherited disorder of repeated fevers and inflammation that often affects the lining of the abdomen, chest, or joints
• Gout
• Hairy cell leukemia -- a type of blood cancer
• Hodgkin disease -- cancer of the lymph tissue
• Inflammatory bowel disease
• Juvenile idiopathic arthritis -- arthritis that affects children
• Multiple myeloma -- a type of blood cancer
• Psoriatic arthritis
• Reactive arthritis -- a group of conditions that causes swelling and inflammation of the joints, eyes, and urinary and genital systems
• Rheumatoid arthritis
• Systemic lupus erythematosus -- an autoimmune disorder
• Tuberculosis
• Vasculitis (inflammation of the blood vessels)

Symptoms of secondary systemic amyloidosis depend on which body tissue is affected by the protein deposits. These deposits damage normal tissues. This may lead to the symptoms or signs of this illness, including:

• Bleeding in the skin
• Fatigue
• Irregular heartbeat
• Numbness of hands and feet
• Rash
• Shortness of breath
• Swallowing difficulties
• Swollen arms or legs
• Swollen tongue
• Weak hand grip
• Weight loss

The condition that is causing the amyloidosis should be treated. In some cases, the drug colchicine or an immunosuppressive medicine (medicine that suppresses the immune system) is prescribed.

How well a person does depends on which organs are affected. It also depends on, whether the disease that is causing it can be controlled. If the disease involves the heart and kidneys, it may lead to organ failure and death.

Health problems that may result from secondary systemic amyloidosis include:

• Endocrine failure
• Heart failure
• Kidney failure
• Nerve damage
• Respiratory failure

Contact your provider if you have symptoms of this condition. The following are serious symptoms that need prompt medical attention:

• Bleeding
• Irregular heartbeat
• Numbness
• Shortness of breath
• Swelling
• Weak grip

If you have a disease that is known to increase your risk for this condition, make sure you get it treated. This may help prevent amyloidosis.

Published Date: April 01, 2025
Published By: Warren Brenner, MD, Oncologist, Lynn Cancer Institute, Boca Raton, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

Gertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.

Papa R, Lachmann HJ. Secondary, AA, amyloidosis. Rheum Dis Clin North Am. 2018;44(4):585-603. PMID: 30274625 pubmed.ncbi.nlm.nih.gov/30274625/.