Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics

Who is this study for? Patients with Epilepsy
What treatments are being studied? Magnetic Resonance Imaging+Intracranial Electroencephalography Recordings
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Patients with medication-refractory epilepsy

• Planned intracranial EEG (IEEG) placement

• Hypothesized to have temporal lobe epilepsy

Locations
United States
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Contact Information
Primary
Kathryn A Davis, MD, MSTR
katedavis@pennmedicine.upenn.edu
215-349-5166
Time Frame
Start Date: 2021-03-01
Estimated Completion Date: 2026-02-28
Participants
Target number of participants: 290
Treatments
Experimental: Epilepsy patient volunteers
Patients recruited for the study with intractable epilepsy who are anticipated to undergo epilepsy surgery
Related Therapeutic Areas
Sponsors
Collaborators: Medical University of South Carolina
Leads: University of Pennsylvania

This content was sourced from clinicaltrials.gov