Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS)
The Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS) study is an effectiveness-implementation hybrid design. The effectiveness evaluation is designed as a multiple interrupted time series (mITS) analysis to test the impact of implementing an adapted Sepsis Transition and Recovery (STAR) program on enhancing post sepsis outcomes in new hospital settings.
• adults 18 years of age and older;
• clinically suspected infection
‣ two or more markers of systemic inflammatory response syndrome within 24 h of presentation; AND
⁃ antibiotics initiated within 24 hours and continued for at least one additional day
• organ dysfunction
‣ two or more points on admission Sequential Organ Failure Assessment (SOFA); OR
⁃ two or more points on admission quick-SOFA
• deemed to be at high risk of hospital readmission within 90 days, defined as readmission risk probability of at least 25%
• not discharged from the hospital at the time of patient identification each morning.