Effect of Albumin Replacement on Oxygen Delivery in Sepsis Patients

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Fluid resuscitation is a critical component of sepsis treatment. Research has shown that intravenous (IV) fluid therapy in sepsis positively impacts cardiac output and thereby oxygen (O2) delivery through a complex interaction of central venous pressure, right atrial pressure, venous resistance, ventricular compliance, cardiac contractility, and systemic vascular resistance. The 2021 sepsis prevention guidelines recommend balanced crystalloids as first-line therapy. However, no studies in the literature have evaluated the effect of albumin on O2 delivery. In our study, the investigators aim to assess the impact of albumin replacement on O2 delivery in sepsis patients in the intensive care unit.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Followed up with a diagnosis of sepsis,

• over 18 years old

• Patients who were diagnosed with hypo-albuminemia after more than 4L/day fluid resuscitation and underwent albumin replacement

Locations
Other Locations
Turkey
Samsun University
RECRUITING
Samsun
Contact Information
Primary
gamze MD ertaş, specialist
gamzeertas555@gmail.com
5056587914
Time Frame
Start Date: 2024-11-15
Estimated Completion Date: 2025-10-15
Participants
Target number of participants: 45
Treatments
group albumin
The effect of albumin replacement on the measurements will be evaluated by calculating the ECHO findings, blood gas parameters and SOFA score of the study patients before and after albumin replacement. Oxygen delivery will be calculated 6 times in total for 3 days and the SOFA score will be calculated 3 times in total once a day.
Related Therapeutic Areas
Sponsors
Leads: Samsun University

This content was sourced from clinicaltrials.gov