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Emergency PanorOmic Wide Association Study in Respiratory Infectious Disease (ePWAS-RID)

Status: Recruiting

Location: See location...

Intervention Type: Diagnostic test

Study Type: Observational

SUMMARY

Develop an emergency PanorOmics Wide Association Study (ePWAS) for the early, rapid biological and pathophysiological characterisation of known and novel Infectious Diseases in adult patients presenting to emergency departments with suspected, acute, community-acquired respiratory infectious disease (scaRID). Phase 1 1. Develop an ED-ID biobank (named ePWAS-RID). Phase 2 2. Targeted research for the discovery of novel diagnostics, prognostics and therapeutics

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 100

Healthy Volunteers: t

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• Patients eligible for enrolment include:

• With reference to previous inclusion criteria are:

• Adults ≥18 years of age; AND

• Suspected, acute, community-acquired, respiratory, infectious disease (scaRID)\*; AND

• Informed consent.

• Note: scaRID is defined according to ALL three criteria:

⁃ Community acquired (not hospitalised for \<28 days); AND

⁃ Acute infection (defined as symptom onset \<8 days and any ONE of reported fever or chills or aural temperature \>37.5°C or hypothermia or leucocytosis or leucopaenia or new altered mental status); AND

⁃ Probable respiratory infection - According to any ONE of:

∙ new cough or new sputum production or

‣ chest pain or

‣ dyspnoea or

‣ tachypnoea or

‣ abnormal lung examination or

‣ respiratory failure; or

‣ physician's judgment (presenting with systemic or gastrointestinal symptoms).

• Control subjects will be drawn from two groups:

• The worried well - adult patients with a National Early Warning Score (NEWS) \<3 and a temperature \<37.5°C.

• Relatives or accompanying friends with no acute illness.

Locations

Other Locations

China

Hong Kong University

RECRUITING

Hong Kong

Contact Information

Primary

Timothy H Rainer, MD

thrainer@hku.hk

+852 39176846

Time Frame

Start Date: 2023-04-11

Estimated Completion Date: 2028-05-01

Participants

Target number of participants: 2000

Treatments

Viral infection

Viral infection subjects presenting within 8 days from symptom onset will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms; and if they agree

Bacterial infection

Bacterial infection subjects presenting within 8 days from symptom onset will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms; and if they agree, a further two samples at b) 24 hours +/- 6 hours from symptom onset (if available); and c) 48 hours +/- 6 hours from symptom onset (if available).

Viral-Viral co-infection

Viral-viral co-infection subjects presenting within 8 days from symptom onset will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms; and if they agree, a further two samples at b) 24 hours +/- 6 hours from symptom onset (if available); and c) 48 hours +/- 6 hours from symptom onset (if available).

Bacterial-Viral co-infection

Bacterial-Viral co-infection subjects presenting within 8 days from symptom onset will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms; and if they agree, a further two samples at b) 24 hours +/- 6 hours from symptom onset (if available); and c) 48 hours +/- 6 hours from symptom onset (if available).

Fungal-Mycobacterium co-infection

Infection of uncertain origin

Infection of uncertain origin subjects presenting within 8 days from symptom onset will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms; and if they agree, a further two samples at b) 24 hours +/- 6 hours from symptom onset (if available); and c) 48 hours +/- 6 hours from symptom onset (if available).

Control Subjects

Control group subjects, if they agree, will have at least one whole blood and saliva drawn a) in the emergency department (if available) or hospital within 8 days of the onset of symptoms (if applicable); and if they agree, a further two samples at b) 24 hours +/- 6 hours from symptom onset (if applicable); and c) 48 hours +/- 6 hours from symptom onset (if applicable).

Related Therapeutic Areas

Pneumonia

Sepsis

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