The Effects of a AN69ST Membrane and Polysulphone Membrane on Septic Children With Continuous Blood Purification
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality. For sepsis, blood purification can remove inflammatory factors in sepsis by filtration or adsorption, so as to achieve the purpose of reducing inflammatory mediators in the body. However, there are few prospective randomized controlled studies in children. Therefore, this study intends to compare the efficacy and prognosis of different membrane on children with sepsis through a perspective cohort study, so as to provide a corresponding basis for the treatment of children with sepsis blood purification.
• Meet the 2005 diagnostic criteria for sepsis
• Age 29 days - 18 years old
• Sepsis-induced dysfunction of more than one organ or abnormal tissue perfusion, or septic shock
• Diagnosis \< 48 hours