Clinical Application of Cytokine Adsorption Technology in AIDS Patients With Severe Pneumonia and/or Septic Shock: An Observational Study.
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Confirmed HIV infection;
• Progression to AIDS stage: CD4+ count \<200 cells/ul and/or occurrence of AIDS opportunistic infections;
• Age between 18 and 65 years;
• Meeting the diagnosis of severe pneumonia or septic shock:
‣ The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia;
⁃ The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's Chinese Guidelines for the Emergency Treatment of Sepsis/Septic Shock (2018).
Locations
Other Locations
China
Guangzhou Eighth People's Hospital, Guangzhou Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Linghua Li, PhD
llheliza@126.com
+862083710825
Backup
Yaozu He, MD
hyzdyl99@163.com
+862083710825
Time Frame
Start Date: 2023-10-23
Estimated Completion Date: 2027-10-23
Participants
Target number of participants: 60
Treatments
Cytokine Adsorption Combined with Standard Treatment Group
This group receives cytokine adsorption combined with standard treatment, specifically via hemoperfusion using the standard 211 protocol: two hemoperfusions within the first 24 hours, followed by one hemoperfusion daily. Each hemoperfusions session does not exceed 6 hours, lasting a total of 3 days. All patients also undergo blood perfusion treatment with the addition of a plasma separator.
Standard Treatment Group
This group receives only standard treatment . Standard treatment includes symptomatic supportive therapy, etiological therapy, fluid resuscitation, application of vasopressors, and non-invasive or invasive ventilation therapy.
Sponsors
Leads: Guangzhou 8th People's Hospital