Precision Resuscitation With Crystalloids in Sepsis (PRECISE)

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis. Multiple clinical studies have compared the two main types of fluids used in sepsis (normal saline and balanced crystalloids). However, these studies have not found a clear benefit of one type of fluid versus the other. Which fluid should be given to which patient is an essential question because of the ubiquity of this intervention. Even a small difference in mortality could drastically change the standards of care given the national (and worldwide) scale of this intervention. The investigators have developed an algorithm that uses bedside vital signs (temperature, heart rate, respiratory rate, and blood pressure) to identify a group of patients (Group D) who have a significant mortality benefit from balanced crystalloids. The study randomizes adult patients admitted through emergency departments across 6 Emory hospitals belonging to Group D to intervention versus usual care. The intervention arm involves a prompt to clinicians to use balanced crystalloids rather than normal saline.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• All adult patients presenting to the Emergency Department, with a blood culture order in the Emergency Department, who are classified as Group D, in whom a clinician initiates a normal saline order

Locations
United States
Georgia
Emory Healthcare System
RECRUITING
Atlanta
Emory Hospital
RECRUITING
Atlanta
Emory Midtown Hospital
RECRUITING
Atlanta
Emory Saint Joseph's Hospital
RECRUITING
Atlanta
Emory Decatur Hospital
RECRUITING
Decatur
Emory Johns Creek Hospital
RECRUITING
Johns Creek
Emory Hillandale Hospital
RECRUITING
Lithonia
Contact Information
Primary
Sivasubramanium Bhavani, MD
sivasubramanium.bhavani@emory.edu
404-712-2970
Time Frame
Start Date: 2024-06-13
Estimated Completion Date: 2026-03
Participants
Target number of participants: 2002
Treatments
Experimental: EHR Alert
Enrolled patients who are classified to Group D by the algorithm will be randomized within the electronic health record to the intervention arm.
Active_comparator: Standard of Care
Enrolled patients who are classified to Group D by the algorithm will be randomized within the electronic health record to usual care.
Related Therapeutic Areas
Sponsors
Leads: Emory University

This content was sourced from clinicaltrials.gov