Specific miRNA Associated With Endothelial Dysfunction and Mitochondrial Damage in Patients With Septic Acute Kidney Injury
Status: Recruiting
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition. The exact pathophysiological mechanism of septic acute kidney injury remains a challenge. One of the possible causes appears to be endothelial dysfunction and mitochondrial damage of renal tubular cells. The aim of this study is to identify specific microRNAs associated with these pathophysiological events in sepsis and septic acute kidney injury. And to establish a new potential diagnostic or therapeutic target for the prevention or treatment of septic acute kidney injury.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
View:
⁃ The study group of patients with sepsis with or without acute kidney injury
• age \> 18 years
• newly diagnosed sepsis or septic shock with or without acute kidney injury
⁃ Healthy volunteers
• no evidence of infection on clinical or laboratory examination
• age \> 18 years
• signed informed consent
Contact Information
Primary
Jiří Hynčica
jiri.hyncica@gmail.com
0042059737
Time Frame
Start Date:2024-05-02
Estimated Completion Date:2027-12-31
Participants
Target number of participants:220
Treatments
Critically ill adult septic patients without acute kidney injury
The patients in this group will be screened clinically and by standard laboratory biochemical methods to determine sepsis diagnosis according to SEPSIS 3 (1). Blood samples for obtaining serum/plasma of the patients will be taken on the 1st and 4th day of sepsis diagnosis.
Critically ill adult septic patients with acute kidney injury
The patients will be screened clinically and by standard laboratory biochemical methods to determine sepsis diagnosis according to SEPSIS 3 and acute kidney injury according to KDIGO 2012 (2). Blood samples for obtaining serum/plasma of the patients will be taken on the 1st and 4th day of sepsis diagnosis.
Healthy volunteers
The blood samples for miRNA and biochemical parameters will be collected once, after randomization.