Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients With Intraabdominal Sepsis: A Randomized Controlled Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• • Adult patients admitted to ICU after ileus surgery (perforated viscus, infarcted bowel, strangulated hernia, anastomotic leakage, diverticulitis, and intestinal obstruction), and who will be expected to require postoperative sedation and ventilation.
⁃ Abdominal sepsis was determined as organ dysfunction with a substantial change in overall SOFA score (2) ≥ 2 points because of intra-abdominal sepsis.
Locations
Other Locations
Egypt
asyut University
RECRUITING
Asyut
Contact Information
Primary
Ahmed Ismail ABDEL sabour, MD
ahmed_ismail87@med.nvu.edu.eg
01097845491
Backup
ayman Mohamed Fawzy, Msc
fawzyayman629@med.nvu.edu.eg
01028697487
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2026-01-01
Participants
Target number of participants: 2
Treatments
Active_comparator: Patients will receive dexmedetomidine
Patients will receive dexmedetomidine (Precedex®; 200 µg/2 ml; at one µg/kg loading dose over 10 minutes followed by a 0.5 µg/kg/hr. maintenance dose for 48 hours Dexmedetomidine will be diluted in normal saline at a 4 µg/ ml concentration
Active_comparator: Patients will receive ketamine
Patients will receive ketamine at one mg/kg IV loading dose over 10 minutes, then a continuous infusion starting at 300 µg /kg/hr over 48 hours
Related Therapeutic Areas
Sponsors
Leads: New Valley University