Initiation of Methylene Blue for Septic Shock in Adults: A Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to evaluate the efficacy and safety of methylene blue among adult patients with septic shock.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:
• age 18 years old or older;
• diagnosis of septic shock within 12 h.
Locations
Other Locations
China
Northern Jiangsu people's hospital
RECRUITING
Yangzhou
Contact Information
Primary
Qingquan Lyu, Master
bonhomie2014@163.com
0086-18051063899
Backup
Xiaohua Gu, Master
njguxiaohua@163.com
0086-18051062325
Time Frame
Start Date: 2024-08-05
Estimated Completion Date: 2026-09
Participants
Target number of participants: 76
Treatments
Experimental: Methylene Blue
Methylene Blue 100mg will be diluted in 40ml 5% dextrose solution. Methylene Blue(1 mg/kg/IBW iv over 30min+0.25mg/kg/h x 6h) x 5-days/ discontinution of norepinephrine /ICU discharge (whichever occurred first).
Placebo_comparator: Placebo
5% dextrose solution in a volume to match experimental arm component.
Related Therapeutic Areas
Sponsors
Leads: Northern Jiangsu People's Hospital