Clinical Study on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Sepsis
Status: Recruiting
Location: See location...
Intervention Type: Other, Biological
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 65
Healthy Volunteers: f
View:
• Age: 0-65 years old, diagnosed with sepsis
• Clinical diagnosis of sepsis (based on Sepsis 3.0 International Guidelines)
• Confirmed or suspected infection
Locations
Other Locations
China
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
RECRUITING
Chongqing
Contact Information
Primary
Xiang Xu, Professor
xiangxu@tmmu.edu.cn
+8613637843870
Time Frame
Start Date: 2025-05-22
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 180
Treatments
Experimental: 135 patients are infused with 1×10⁸ stem cells per session
Sham_comparator: 45 patients are infused with equal volume of control solution
Related Therapeutic Areas
Sponsors
Leads: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University