COMBAT-SAB: Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremia
Status: Recruiting
Location: See all (13) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The purpose of this study is to see if, in selected patients with a serious bacterial infection of the bloodstream, treating the bacterial infection with a combination of antibiotics is more effective than treating the infection with a single antibiotic. Participants must have blood cultures which are positive for a certain type of bacteria.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years
• Alive and admitted to an Intermountain Health (IH) hospital acute care unit at enrollment
• Initial positive blood culture with either methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA), collected:
‣ on or during the index admission to an IH hospital, or
⁃ in an ambulatory setting (laboratory, clinic or emergency department) within 48 hours of the index admission, or
⁃ at a non-IH network hospital within 24 hours of subsequent transfer to an IH hospital
Locations
United States
Colorado
Platte Valley Hospital
NOT_YET_RECRUITING
Brighton
Saint Joseph Hospital
NOT_YET_RECRUITING
Denver
St. Mary's Regional Hospital
NOT_YET_RECRUITING
Grand Junction
Good Samaritan Hospital
NOT_YET_RECRUITING
Lafayette
Lutheran Medical Center
NOT_YET_RECRUITING
Wheat Ridge
Montana
St. Vincent Regional Hospital
NOT_YET_RECRUITING
Billings
St. James Hospital
NOT_YET_RECRUITING
Butte
Holy Rosary Hospital
NOT_YET_RECRUITING
Miles City
Utah
Intermountain Medical Center
RECRUITING
Murray
McKay-Dee Hospital
NOT_YET_RECRUITING
Ogden
Utah Valley Hospital
NOT_YET_RECRUITING
Provo
LDS Hospital
NOT_YET_RECRUITING
Salt Lake City
St. George Regional Hospital
NOT_YET_RECRUITING
St. George
Contact Information
Primary
Brandon J Webb, MD
Brandon.Webb@imail.org
801-507-7781
Backup
Whitney R Buckel, PharmD
Whitney.Buckel@imail.org
801-284-1046
Time Frame
Start Date:2026-02-01
Estimated Completion Date:2029-01
Participants
Target number of participants:2096
Treatments
Experimental: Patients with methicillin-sensitive S. aureus bacteremia (MSSAB)
Patients with methicillin-sensitive S. aureus bacteremia (MSSAB) will be assigned to one of two different antibiotic treatment strategies appropriate for MSSA: 1) antibiotic monotherapy, or 2) combination antibiotic therapy
Experimental: Patients with methicillin-resistant S. aureus bacteremia (MRSAB)
Patients with methicillin-resistant S. aureus bacteremia (MRSAB) will be assigned to one of two different antibiotic treatment strategies appropriate for MRSA: 1) antibiotic monotherapy, or 2) combination antibiotic therapy