Severe Combined Immunodeficiency (SCID) Overview

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Learn About Severe Combined Immunodeficiency (SCID)

What is the definition of Severe Combined Immunodeficiency (SCID)?
Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by abnormalities with responses of both T cells and B cells (specific types of white blood cells needed for immune system function). Common signs and symptoms include an increased susceptibility to infections including ear infections; pneumonia or bronchitis; oral thrush; and diarrhea. Due to recurrent infections, children with SCID do not grow and gain weight as expected (failure to thrive). SCID may be caused by genetic changes in any of several genes and can be inherited in an X-linked recessive (most commonly) or autosomal recessive manner. The most common type of SCID is called X-linked Severe combined immunodeficiency (XSCID). Another form of SCID is caused by a deficiency of the enzyme adenosine deaminase (ADA).
What are the alternative names for Severe Combined Immunodeficiency (SCID)?
  • Severe combined immunodeficiency
  • SCID
Who are the top Severe Combined Immunodeficiency (SCID) Local Doctors?
Dr. Theodore B. Moore
Pediatric Hematology Oncology | Pediatrics
Dr. Theodore B. Moore
Pediatric Hematology Oncology | Pediatrics
10833 Le Conte Ave, 12-441 Mdcc, 
Los Angeles, CA 
 (11.7 mi)
310-825-6708
Languages Spoken:
English

Theodore Moore is a Pediatric Hematologist Oncology specialist and a Pediatrics provider in Los Angeles, California. Dr. Moore and is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Severe Combined Immunodeficiency (SCID), Sickle Cell Disease, Congenital Hemolytic Anemia, Bone Marrow Transplant, and Bone Marrow Aspiration.

Dr. Donald B. Kohn
Pediatric Hematology Oncology | Pediatrics
Dr. Donald B. Kohn
Pediatric Hematology Oncology | Pediatrics
4650 W Sunset Blvd, Ms# 62, 
Los Angeles, CA 
 (18.7 mi)
323-669-4559
Languages Spoken:
English
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Donald Kohn is a Pediatric Hematologist Oncology specialist and a Pediatrics provider in Los Angeles, California. Dr. Kohn and is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Severe Combined Immunodeficiency (SCID), Adenosine Deaminase Deficiency, X-Linked Severe Combined Immunodeficiency, Hemoglobinopathy, and Bone Marrow Transplant.

 
 
 
 
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Michael A. Pulsipher
Dr. Michael A. Pulsipher
Pediatric Hematology Oncology | Hematology Oncology | Pediatrics
Dr. Michael A. Pulsipher
Pediatric Hematology Oncology | Hematology Oncology | Pediatrics
4650 W Sunset Blvd, Mail Stop #54, 
Los Angeles, CA 
 (18.7 mi)
323-361-2546
Languages Spoken:
English, Japanese
See accepted insurances
Accepting New Patients
Offers Telehealth

Michael Pulsipher is a Pediatric Hematologist Oncology specialist and a Hematologist Oncology provider in Los Angeles, California. Dr. Pulsipher and is rated as a Distinguished provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Graft Versus Host Disease (GvHD), Leukemia, Severe Combined Immunodeficiency (SCID), and Bone Marrow Transplant. Dr. Pulsipher is currently accepting new patients.

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What are the latest Severe Combined Immunodeficiency (SCID) Clinical Trials?
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Who is this study for: Child to adult male patients with Severe Combined Immune Deficiency
Enrollment Status: Recruiting
Publish Date: February 24, 2025
Intervention Type: Biological, Drug
Study Drugs: Palifermin, Busulfan, Autologous CD34-Positive VSV-G Pseudotyped CL20-4i-EF1a-hyc-OPT Vector Hematopoietic Stem Cell Infusion
Study Phase: Phase 1/Phase 2

Summary: This is a Phase I/II non-randomized clinical trial of ex vivo hematopoietic stem cell (HSC) gene transfer treatment for X-linked severe combined immunodeficiency (XSCID, also known as SCID-X1) using a self-inactivating lentiviral vector incorporating additional features to improve safety and performance. The study will treat 35 patients with XSCID who are between 2 and 50 years of age and who have...

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Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect
Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect
Enrollment Status: Recruiting
Publish Date: February 12, 2025

Summary: Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions. With a simple blood test, rare genetic conditions can be easily detected, and the early start of transformative treatment will help avoid severe disabilities and increase the quality of life. Baby Detect Project is an innovative NBS program using a pane...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center