Severe Combined Immunodeficiency (SCID)
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Severe Combined Immunodeficiency (SCID) Overview

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Learn About Severe Combined Immunodeficiency (SCID)

What is the definition of Severe Combined Immunodeficiency (SCID)?
Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by abnormalities with responses of both T cells and B cells (specific types of white blood cells needed for immune system function). Common signs and symptoms include an increased susceptibility to infections including ear infections; pneumonia or bronchitis; oral thrush; and diarrhea. Due to recurrent infections, children with SCID do not grow and gain weight as expected (failure to thrive). SCID may be caused by genetic changes in any of several genes and can be inherited in an X-linked recessive (most commonly) or autosomal recessive manner. The most common type of SCID is called X-linked Severe combined immunodeficiency (XSCID). Another form of SCID is caused by a deficiency of the enzyme adenosine deaminase (ADA).
What are the alternative names for Severe Combined Immunodeficiency (SCID)?
  • Severe combined immunodeficiency
  • SCID
Who are the top Severe Combined Immunodeficiency (SCID) Local Doctors?
Elite in Severe Combined Immunodeficiency (SCID)
Andrew R. Gennery
Elite in Severe Combined Immunodeficiency (SCID)
Andrew R. Gennery
Referral may be required
Queen Victoria Road, 
Newcastle Upon Tyne, ENG, GB 

Andrew Gennery practices practicing medicine in Newcastle Upon Tyne, United Kingdom. Mr. Gennery is rated as an Elite expert by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Severe Combined Immunodeficiency (SCID), Primary Immunodeficiency (PID), Chronic Granulomatous Disease, Bone Marrow Transplant, and Heart Transplant.

Elite in Severe Combined Immunodeficiency (SCID)
Dr. Christopher Dvorak
Hematology | Oncology
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Christopher Dvorak
Hematology | Oncology
Referral may be required

Office

550 16th St Fl 4, 
San Francisco, CA 
415-476-0554
Languages Spoken:
English
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Christopher Dvorak is a Hematologist and an Oncologist practicing medicine in San Francisco, California. Dr. Dvorak is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Severe Combined Immunodeficiency (SCID), Juvenile Myelomonocytic Leukemia (JMML), Hepatic Venoocclusive Disease with Immunodeficiency, Bone Marrow Transplant, and Splenectomy.

 
 
 
 
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Elite in Severe Combined Immunodeficiency (SCID)
Ansgar S. Schulz
Elite in Severe Combined Immunodeficiency (SCID)
Ansgar S. Schulz
Referral may be required
Marburger Str. 85, 
Kassel, HE, DE 

Ansgar Schulz practices practicing medicine in Kassel, Germany. Schulz is rated as an Elite expert by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). They are also highly rated in 31 other conditions, according to our data. Their clinical expertise encompasses Osteopetrosis, Severe Combined Immunodeficiency (SCID), CLN2 Disease, Bone Marrow Transplant, and Splenectomy.

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What are the latest Severe Combined Immunodeficiency (SCID) Clinical Trials?
The Determination of Genetic Basis Of Immunodeficiency
The Determination of Genetic Basis Of Immunodeficiency
Enrollment Status: Recruiting
Publish Date: June 18, 2026

Summary: This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates include: * Patients with diminished numbers of T cells or NK cells or both, or * Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of patients wil...

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Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Who is this study for: Child to adult male patients with Severe Combined Immune Deficiency
Enrollment Status: Recruiting
Publish Date: June 18, 2026
Intervention Type: Biological, Drug
Study Drugs: Palifermin, Busulfan, Autologous CD34-Positive VSV-G Pseudotyped CL20-4i-EF1a-hyc-OPT Vector Hematopoietic Stem Cell Infusion
Study Phase: Phase 1/Phase 2

Summary: This is a Phase I/II non-randomized clinical trial of ex vivo hematopoietic stem cell (HSC) gene transfer treatment for X-linked severe combined immunodeficiency (XSCID, also known as SCID-X1) using a self-inactivating lentiviral vector incorporating additional features to improve safety and performance. The study will treat 35 patients with XSCID who are between 2 and 50 years of age and who have...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center