Shingles (also known as herpes zoster) results from infection by the varicella zoster virus. This common virus causes chickenpox (also known as varicella), which is characterized by itchy spots on the skin that cover the whole body and usually occurs in childhood or adolescence. After the body fights the initial infection, the varicella zoster virus remains in nerve cells for the rest of a person's life. Because the virus is controlled by immune system cells called T cells, it is generally inactive (latent) and typically causes no health problems. However, in some people, the virus becomes active again (reactivates) and causes shingles. Shingles can occur at any age, although it is rare in childhood and becomes more common after age 50.
The causes of shingles are complex. Development of the condition is influenced by a combination of factors, including age, health, and genetics.
Because everyone infected with the varicella zoster virus is at risk of developing shingles, the condition is relatively common, particularly in older adults. Shingles occurs in 20 to 30 percent of people at some point in their lives, and about half of people over age 80 have had shingles.
The inheritance pattern of shingles is unclear. Having a first-degree relative (such as a parent or sibling) who developed shingles appears to slightly increase the risk of developing the condition. However, shingles is relatively common in the general population, particularly among older adults, and so it would not be surprising to see more than one case in a family just by chance.
Kevin Winthrop is an Infectious Disease expert in Portland, Oregon. Winthrop has been practicing medicine for over 25 years and is rated as an Elite expert by MediFind in the treatment of Shingles. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Mycobacterium Avium Complex Infections, Shingles, Nontuberculous Mycobacterial Lung Disease, Cataract Removal, and Knee Replacement. Winthrop is currently accepting new patients.
Desmond Curran practices in Waver, Belgium. Curran is rated as an Elite expert by MediFind in the treatment of Shingles. He is also highly rated in 2 other conditions, according to our data. His top areas of expertise are Shingles, Neuralgia, Chickenpox, Pertussis, and Hormone Replacement Therapy (HRT).
Myron Levin is a Pediatric Infectious Disease specialist and an Infectious Disease expert in Aurora, Colorado. Levin has been practicing medicine for over 59 years and is rated as an Elite expert by MediFind in the treatment of Shingles. He is also highly rated in 5 other conditions, according to our data. His top areas of expertise are Shingles, Chickenpox, Flu, and Human Papillomavirus Infection. Levin is currently accepting new patients.
Background: Shingles is a painful, blistering rash caused by the same virus that causes chickenpox. Shingrix is a vaccine approved to prevent shingles in healthy adults over age 50 and in immunocompromised adults over age 18. Researchers want to learn more about how people with HIV respond to Shingrix.
Summary: The purpose of this study is to assess the safety and immunogenicity of CRV-101, an investigational vaccine compared to Shingrix for the prevention of herpes zoster in adults aged 50 years and older
Published Date: January 01, 2018Published By: National Institutes of Health