Sick Sinus Syndrome Clinical Trials

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Comparison of Left Bundle Branch Area Pacing and Minimized Ventricular Pacing in Patients With Sinus Node Dysfunction and Atrioventricular Conduction Delay: A Multicenter, Randomized Controlled Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare two pacemaker strategies: Left Bundle Branch Area Pacing (LBBAP) and Minimized Ventricular Pacing (MVP) in patients requiring a permanent pacemaker for sick sinus syndrome and prolonged AV interval. It will also evaluate the safety and feasibility of the LBBAP method in these patients. The main questions it aims to answer is: \*Is LBBAP with physiological AV interval better than Minimized Ventricular Pacing? Researchers will compare the LBBAP group (aiming for conduction system capture with physiological AV intervals) to the MVP group (aiming to minimize ventricular pacing with prolonged AV intervals) to evaluate the optimal pacing strategy. Participants will: * Be randomly assigned to either the LBBAP group or the MVP group. * Undergo a pacemaker implantation procedure according to the specific criteria for their assigned group. * Visit the clinic for regular checkups to measure pacing function and ensure the device settings remain compliant with the study protocol.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• \>18 years old

• Sinus node dysfunction with symptoms

• Atrioventricular conduction delay (PR interval \> 200ms)

Locations
Other Locations
Republic of Korea
Asan Medical Center
RECRUITING
Seoul
Time Frame
Start Date: 2025-05-02
Estimated Completion Date: 2029-01-31
Participants
Target number of participants: 440
Treatments
Experimental: LBBAP
Active_comparator: MVP
Related Therapeutic Areas
Sponsors
Collaborators: Seoul National University Hospital, Samsung Medical Center, Severance Hospital
Leads: Asan Medical Center

This content was sourced from clinicaltrials.gov