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Condition

Situs Inversus

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Situs Inversus?

Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about ...

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What are the alternative names for Situs Inversus?

  • Situs inversus viscerum
  • SIV

What are the symptoms for Situs Inversus?

In isolated situs inversus (occurring alone with no other abnormalities), there is a complete mirror image transposition of the thoracic (chest) and abdominal organs, and anterior-posterior (front-back) symmetry is normal. Many affected people have no associated health issues when the condition is isolated. When situs inversus occurs in association with other conditions such as Kartagener syndrome or primary ciliary dyskinesia, additional signs and symptoms relating to these conditions will be present.

What are the current treatments for Situs Inversus?

In isolated situs inversus, no treatment may be necessary. When situs inversus is associated with another condition, treatment may depend on the associated condition and the signs and symptoms present in the affected person.

Knowing that a person has situs inversus is important for diagnosing medical problems and preventing surgical mishaps that can result from the failure to recognize reversed anatomy. For example, in a person with situs inversus, appendicitis causes pain in the left lower abdomen instead of the right lower abdomen. Wearing medical identification can help ensure proper treatment in an emergency medical situation.

What is the outlook (prognosis) for Situs Inversus?

The long-term outlook (prognosis) for people with situs inversus depends on whether the condition is isolated, or is associated additional abnormalities affecting the heart or other parts of the body. Isolated situs inversus has an excellent prognosis, typically with an uneventful prenatal and postnatal course. When situs inversus is associated with an underlying condition or syndrome, the prognosis may depend on that of the underlying condition present.

For fetuses diagnosed with situs inversus on prenatal ultrasound, additional testing such as fetal MRI and fetal echocardiography may provide additional information about the development of the fetus, which may affect management and prognosis. Additional imaging tests are also recommended after birth to further clarify any associated abnormalities that may be present. People who learn of a diagnosis made by prenatal ultrasound are encouraged to meet with a genetic counselor or other genetics professional.

Knowing that a person has situs inversus is important for diagnosing medical problems and preventing surgical mishaps that can result from the failure to recognize reversed anatomy. For example, in a person with situs inversus, appendicitis causes pain in the left lower abdomen instead of the right lower abdomen. Wearing medical identification can help ensure proper treatment in an emergency medical situation.

Is Situs Inversus an inherited disorder?

The genetics of situs inversus is complex. Several familial cases have been reported in which the inheritance has been described as either autosomal recessive (most commonly), autosomal dominant, or X-linked. The condition appears to be genetically heterogeneous, meaning that different genetic factors or genes may cause the condition among different people or families. If situs inversus is associated with another underlying syndrome or condition, the inheritance pattern may be the same as that of the underlying condition.

People with questions about genetic risks to themselves or family members are encouraged to speak with a genetics professional.

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Latest Research

Latest Advance
Study
  • Condition: Congenital Duodenal Atresia with Situs Inversus Abdominis in a Newborn
  • Journal: Medicine
  • Treatment Used: Diamond-shaped Duodenoduodenostomy with Appendectomy
  • Number of Patients: 1
  • Published —
The study researched the outcomes of a newborn with diamond-shaped duodenoduodenostomy with appendectomy.
Latest Advance
Study
  • Condition: Late-Onset Symptoms of Erythrocytosis in Univentricular Dextrocardia
  • Journal: Medicine
  • Treatment Used: Intravenous Hydration Therapy with Normal Saline
  • Number of Patients: 1
  • Published —
This case report discusses a 54-year-old male with f univentricular dextrocardia (right pointing heart), pulmonary hypertension (high blood pressure), and secondary erythrocytosis (high red blood cells) treated with intravenous hydration therapy with normal saline.

Clinical Trials

Clinical Trial
Other
  • Status: Recruiting
  • Study Type: Other
  • Participants: 26
  • Start Date: March 4, 2019
Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia
Clinical Trial
Drug
  • Status: Recruiting
  • Study Type: Drug
  • Participants: 50
  • Start Date: September 20, 2018
Transposition of the Great Arteries: Prenatal Anatomical and Hemodynamic Findings Associated With Perinatal Outcomes