Learn About Small Lymphocytic Lymphoma (SLL)

What is the definition of Small Lymphocytic Lymphoma (SLL)?
Small lymphocytic lymphoma, also called chronic lymphocytic leukemia, is a slow-growing cancer known as non-Hodgkin lymphoma. Small lymphocytic leukemia involves immature white blood cells called lymphocytes. Lymphocytes are cells that fight infection. While chronic lymphocytic leukemia mainly affects the blood and bone marrow, small lymphocytic lymphoma mainly affects the lymph nodes.
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What are the symptoms of Small Lymphocytic Lymphoma (SLL)?
Symptoms of small lymphocytic lymphoma may not appear for many years. Symptoms of small lymphocytic lymphoma may at first be mild and include discomfort and feeling unwell. As small lymphocytic lymphoma slowly progresses, symptoms depend on the location of the tumor and may include fatigue; shortness of breath; swollen, painless lymph nodes; anemia; bleeding; bruising easily; bone pain; fever; night sweats; abdominal swelling; abdominal pain; feeling full after eating a small amount; unexplained weight loss; an enlarged spleen; and frequent infections.
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What are the current treatments for Small Lymphocytic Lymphoma (SLL)?
Treatment for small lymphocytic lymphoma depends on the symptoms, the rate at which the cancer is progressing, and an individual’s particular genetic mutations, age, and overall health. Initial treatment for individuals with small lymphocytic lymphoma without symptoms may include watchful waiting. As small lymphocytic lymphoma progresses, treatment may include combination targeted therapies and immunotherapies, such as ibrutinib with or without rituximab, ibrutinib and Obinutuzumab, venetoclax with or without rituximab, venetoclax with Obinutuzumab, and alemtuzumab. Chemotherapy is now rarely used to treat small lymphocytic lymphoma; however, it may still be a treatment option and is usually used in combination with targeted therapies and immunotherapies, such as chlorambucil and Obinutuzumab; fludarabine, cyclophosphamide, and rituximab; ofatumumab and chlorambucil; rituximab and chlorambucil; bendamustine; and corticosteroids, such as dexamethasone and prednisone. Maintenance therapy for patients with small lymphocytic lymphoma who have responded to treatment may include ofatumumab, rituximab, and lenalidomide. Patients with relapsed/refractory small lymphocytic lymphoma may be treated with ibrutinib with or without rituximab or Obinutuzumab, venetoclax with or without rituximab or Obinutuzumab, idelalisib and rituximab or Obinutuzumab, acalabrutinib with or without rituximab or Obinutuzumab, duvelisib, and lenalidomide with or without rituximab. Treatment with allogenic stem cell (bone marrow) transplant from a living donor may provide a cure for patients with small lymphocytic lymphoma but carries a risk of complications. Supportive care for patients with small lymphocytic lymphoma may also include vaccinations to prevent infections. Long-term follow-up for patients with small lymphocytic lymphoma is necessary to monitor disease progression, treatment effects, and to prevent and treat any infections.
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What are the latest Small Lymphocytic Lymphoma (SLL) Clinical Trials?
Phase 1/2 Dose Escalation Study of CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. About 90% of children and young adults who are treated for ALL can now be cured. But if the disease comes back, the survival rate drops to less than 50%. Better treatments are needed for ALL relapses.

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A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Summary: The purpose of this study is to compare the efficacy and safety of pirtobrutinib (LOXO-305; Arm A) compared to BR (Arm B) in patients with CLL/SLL who have not been treated. Participation could last up to five years.

What are the Latest Advances for Small Lymphocytic Lymphoma (SLL)?
Zanubrutinib in patients with previously treated B-cell malignancies intolerant of previous Bruton tyrosine kinase inhibitors in the USA: a phase 2, open-label, single-arm study.
Research Progress of Oral BCL-2 Inhibitor Venetoclax in the Treatment of Non-Hodgkin's Lymphoma --Review.
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CLL-118 A Phase 1 Study With the Novel B-Cell Lymphoma 2 Inhibitor BGB-11417 as Monotherapy or in Combination With Zanubrutinib in Patients With B-Cell Malignancies: Preliminary Data.