Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Males and females of diverse racial and ethnic background;
• Age 18-80 years;
• Native English speakers;
• Right-handed;
• Normal cognitive status;
• Patients will have laryngeal dystonia or voice tremor;
• Healthy controls will be healthy individuals without neurological, psychiatric or otolaryngological problems.
Locations
United States
Massachusetts
Massachusetts Eye and Ear and University of California San Francisco
RECRUITING
Boston
Contact Information
Primary
Kristina Simonyan, MD, PhD
simonyan_lab@meei.harvard.edu
617-573-6016
Time Frame
Start Date: 2022-03-24
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 165
Treatments
Other: Spatial and temporal CNS pathophysiology of laryngeal dystonia and voice tremor
Simultaneous fMRI with EEG and MEG imaging will be used to examine neural dynamics during phonation.
Active_comparator: Sensorimotor modulations of laryngeal dystonia and voice tremor with bupivacaine
Topical laryngeal block (1 ml of 0.75% bupivacaine solution) will be used to modulate somatosensory feedback from the laryngeal mucosa during speech production and examine associated changes in brain activity.
Other: Motor learning and CNS pathophysiology of laryngeal dystonia and voice tremor
Implicit learning of the production of motor sequences will be examined during simultaneous fMRI/EEG and MEG imaging.~Sensorimotor adaptation of speech production during MEG imaging will be examined during perturbing pitch or formants of auditory feedback consistently during speech production and examining the behavioral and neural correlates of the resulting across-trial adaptation responses.
Placebo_comparator: Placebo effects in laryngeal dystonia and voice tremor
1 ml of saline placebo matching to 1 ml of 0.75% bupivacaine solution will be used for a comparison with the topical laryngeal block to modulate somatosensory feedback from the laryngeal mucosa during speech production and examine associated changes in brain activity.
Other: Auditory feedback processing in laryngeal dystonia and voice tremor
The role of auditory feedback processing on task-induced speech sensorimotor activity will be examined using MEG imaging during perturbing pitch or formants of auditory feedback, unpredictably during speech production, and examining the behavioral and neural correlates of the resulting within-trial compensation responses.
Authors
Srikantan Nagarajan
Related Therapeutic Areas
Sponsors
Leads: Massachusetts Eye and Ear Infirmary
Collaborators: University of California, San Francisco