Learn About Spastic Paraplegia Type 3A

What is the definition of Spastic Paraplegia Type 3A?

Spastic paraplegia type 3A is one of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by muscle stiffness (spasticity) and weakness in the lower limbs (paraplegia). Hereditary spastic paraplegias are often divided into two types: pure and complex. The pure types involve only the lower limbs, while the complex types also involve other areas of the body; additional features can include changes in vision, changes in intellectual functioning, difficulty walking, and disturbances in nerve function (neuropathy). Spastic paraplegia type 3A is usually a pure hereditary spastic paraplegia, although a few complex cases have been reported.

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What are the causes of Spastic Paraplegia Type 3A?

Mutations in the ATL1 gene cause spastic paraplegia type 3A. The ATL1 gene provides instructions for producing a protein called atlastin-1. Atlastin-1 is produced primarily in the brain and spinal cord (central nervous system), particularly in nerve cells (neurons) that extend down the spinal cord (corticospinal tracts). These neurons send electrical signals that lead to voluntary muscle movement. Atlastin-1 is involved in the growth of specialized extensions of neurons, called axons, which transmit nerve impulses that signal muscle movement. The protein also likely plays a role in the normal functioning of multiple structures within neurons and in distributing materials within these cells.

How prevalent is Spastic Paraplegia Type 3A?

Spastic paraplegia type 3A belongs to a subgroup of hereditary spastic paraplegias known as autosomal dominant hereditary spastic paraplegia, which has an estimated prevalence of 2 to 9 per 100,000 individuals. Spastic paraplegia type 3A accounts for 10 to 15 percent of all autosomal dominant hereditary spastic paraplegia cases.

Is Spastic Paraplegia Type 3A an inherited disorder?

Spastic paraplegia type 3A is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In approximately 95 percent of cases, an affected person inherits the mutation from one affected parent.

Who are the top Spastic Paraplegia Type 3A Local Doctors?
Distinguished
Highly rated in
14
conditions
Physiatry

EvergreenHealth

EvergreenHealth Multiple Sclerosis Center

12039 Ne 128th St 
Kirkland, WA 98034

Theodore Brown is a Physiatrist in Kirkland, Washington. Dr. Brown has been practicing medicine for over 33 years and is rated as a Distinguished doctor by MediFind in the treatment of Spastic Paraplegia Type 3A. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Relapsing Multiple Sclerosis, Spastic Paraparesis, Spastic Paraplegia-Epilepsy-Intellectual Disability Syndrome, and Spastic Paraplegia Type 2. He is licensed to treat patients in Washington. Dr. Brown is currently accepting new patients.

Distinguished
Highly rated in
11
conditions
Neurology

Mass General Brigham

15 Parkman St Office

15 Parkman St 
Boston, MA 2114

Craig Blackstone is a Neurologist in Boston, Massachusetts. Dr. Blackstone has been practicing medicine for over 28 years and is rated as a Distinguished doctor by MediFind in the treatment of Spastic Paraplegia Type 3A. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Spastic Paraplegia Type 7, Spastic Paraplegia Type 4, Paraplegia, and Spasticity. He is licensed to treat patients in Massachusetts.

 
 
 
 
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Distinguished
Highly rated in
25
conditions
Physiatry
Neurology

Cleveland Clinic Health System

Cleveland Clinic Main Campus

9500 Euclid Ave 
Cleveland, OH 44195

Keith Mckee is a Physiatrist and a Neurologist in Cleveland, Ohio. Dr. Mckee has been practicing medicine for over 21 years and is rated as a Distinguished doctor by MediFind in the treatment of Spastic Paraplegia Type 3A. He is also highly rated in 25 other conditions, according to our data. His top areas of expertise are Spastic Paraplegia Type 5A, Spastic Paraplegia Type 2, Spastic Paraplegia Type 11, and Spastic Paraplegia Type 3A. He is licensed to treat patients in Ohio. Dr. Mckee is currently accepting new patients.

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Who are the sources who wrote this article ?

Published Date:updated Last, March

Published By: National Institutes of Health

What are the Latest Advances for Spastic Paraplegia Type 3A?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.