Spastic Paraplegia Type 4 Latest Advances

Fampridine in Hereditary Spastic Paraplegia Type 4 With SPAST Variant c.683-2A>C: A Case Report.

Journal: The American journal of case reports

Published: January 07, 2026

Serum NfL, but not GFAP, differentiates primary lateral sclerosis from adrenomyeloneuropathy and hereditary spastic paraplegia type 4.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration

Published: September 17, 2025

Genotype-Phenotype Distinctions in Spastic Paraplegia 4 Reveal HDAC6 as a Therapeutic Target.

Journal: bioRxiv : the preprint server for biology

Published: August 12, 2025

Expanding the Phenotypic Spectrum of SPG4: Autism Spectrum Disorder in Early-Onset and Complex SPAST-HSP and Case Study.

Journal: Genes

Published: July 17, 2025

Spinal cord structural changes in SPG4: insights from a large cohort using advanced neuroimaging.

Journal: Journal of neurology

Published: June 18, 2025

Intracerebroventricular SPAST-AAV9 gene therapy prevents the manifestation of symptoms in a mouse model of SPG4 Hereditary Spastic Paraplegia.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: April 14, 2025

Structural brain changes contributing to motor signs in pure hereditary spastic paraplegia type 4.

Journal: Journal of neurology

Published: February 19, 2025

Subclinical involvement of central nervous system structures other than motor or sensory tracts in SPG3A and SPG4 patients.

Journal: BMC neurology

Published: January 10, 2025

Mild cognitive dysfunction in hereditary spastic paraplegia 4 disease related to fluorodesoxyglucose cerebral positron emission tomography.

Journal: Brain communications

Published: January 09, 2025

Unraveling Isoform Complexity: The Roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4).

Journal: Movement disorders : official journal of the Movement Disorder Society

Published: August 26, 2024

Novel de novo SPAST mutation in a Han Chinese SPG4 patient: a case report.

Journal: Frontiers in genetics

Published: April 05, 2024

Advance of research on Hereditary spastic paraplegia type 4

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Published: January 03, 2024