Effect of Combined ES Cycling Training on Individuals With SCA

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

To focuses on the challenges faced by individuals with spinocerebellar ataxia (SCA), highlighting the major clinical sign of ataxia that affects their stability and ability to perform daily activities, thereby impacting their quality of life. It outlines the concept of neural plasticity, which is the brain's ability to adapt through changes in excitability, and notes that these changes are more enduring in the central nervous system (CNS) than in the peripheral nervous system (PNS). This adaptability, crucial for memory and motor learning, is compromised in SCA patients due to impaired brain areas and pathways. The summary further delves into motor learning, distinguishing between explicit and implicit learning, and points out that SCA patients exhibit deficiencies in procedural learning and cerebellar function. It also introduces the concept of priming as a preparatory mechanism that can enhance the effectiveness of physical therapy by modifying subsequent responses to stimuli. The document suggests that cycling, as an aerobic exercise, could prime the brain for improved blood flow and oxygenation, thereby supporting synaptic plasticity and the release of beneficial neurotrophic factors. Finally, the project aims to deepen the understanding of motor performance and learning mechanisms in SCA patients and apply these insights to clinical rehabilitation strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: t
View:

• \- Clinical diagnosis of SCA.

Locations
Other Locations
Taiwan
Chang Gung University
RECRUITING
Taoyuan District
Contact Information
Primary
Ya-Ju Chang, PhD
yjchang@mail.cgu.edu.tw
88632118800
Time Frame
Start Date: 2022-04-08
Estimated Completion Date: 2025-07-31
Participants
Target number of participants: 145
Treatments
No_intervention: Stage 1: Healthy people
To establish a baseline and ensure reliability, and to develop a training protocol for stage 3.
Experimental: Stage 2: Short-term training SCA people
Short-term ES Cycling Training
No_intervention: Stage 2: SCA Control group
Control Group
Experimental: Stage 3:Long-term training SCA people
Long-term ES Cycling Training
No_intervention: Stage 3: SCA Control group
Control group
Sponsors
Leads: Chang Gung University

This content was sourced from clinicaltrials.gov

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