Split Hand Foot Malformation Symptoms, Doctors, Treatments, Advances & More

Learn About Split Hand Foot Malformation

What is the definition of Split Hand Foot Malformation?

Split hand foot malformation (SHFM) is a type of birth defect that consists of missing digits (fingers and/or toes), a deep cleft down the center of the hand or foot, and fusion of remaining digits. The severity of this condition varies widely among affected individuals. SHFM is sometimes called ectrodactyly; however, this is a nonspecific term used to describe missing digits. SHFM may occur by itself (isolated) or it may be part of a syndrome with abnormalities in other parts of the body. At least six different forms of isolated SHFM have been described. Each type is associated with a different underlying genetic cause. SHFM1 has been linked to chromosome 7, and SHFM2 is linked to the X chromosome. SHFM3 is caused by a duplication of chromosome 10 at position 10q24. Changes in the TP63 gene cause SHFM4. SHFM5 is linked to chromosome 2, and SHFM6 is caused by genetic changes in the WNT10B gene. SHFM may be inherited in an autosomal dominant, autosomal recessive, or X-linked manner.

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What are the alternative names for Split Hand Foot Malformation?

Split hand foot malformation
Ectrodactyly
SHFM

Who are the top Split Hand Foot Malformation Local Doctors?

Laura Southgate

Elite

Highly rated in

conditions

King's College London

Division Of Psychological Medicine,

London, ENG, GB

Laura Southgate practices in London, United Kingdom. Southgate is rated as an Elite expert by MediFind in the treatment of Split Hand Foot Malformation. She is also highly rated in 8 other conditions, according to our data. Her top areas of expertise are Split Hand Foot Malformation, Aplasia Cutis Congenita, Clouston Syndrome, and Ectodermal Dysplasias.

Florence Petit

Distinguished

Highly rated in

conditions

Centre De Référence Des Maladies Neuromusculaires, CHRU Lille

Lille, FR

Florence Petit practices in Lille, France. Petit is rated as a Distinguished expert by MediFind in the treatment of Split Hand Foot Malformation. She is also highly rated in 39 other conditions, according to our data. Her top areas of expertise are Cleft Hand Absent Tibia, Split Hand Foot Malformation, Blepharocheilodontic Syndrome, and Chromosome 4q Duplication.

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Maki Fukami

Distinguished

Highly rated in

conditions

National Center For Child Health And Development

Tokyo, JP

Maki Fukami practices in Tokyo, Japan. Fukami is rated as a Distinguished expert by MediFind in the treatment of Split Hand Foot Malformation. They are also highly rated in 62 other conditions, according to our data. Their top areas of expertise are Russell-Silver Dwarfism, Intersex, Idiopathic Short Stature (ISS), and Short Stature (Growth Disorders).

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What are the latest Split Hand Foot Malformation Clinical Trials?

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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