Condition 101 About Squamous Cell Skin Carcinoma

What is the definition of Squamous Cell Skin Carcinoma?

Squamous cell carcinoma (SCC) is the second most common skin cancer. SCC most often affects individuals who are exposed to large amounts of sunlight. It is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. Most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. The most common causes of SCC are radiation from the sun and arsenic exposure. With appropriate treatment, it is usually curable.

What are the alternative names for Squamous Cell Skin Carcinoma?

  • Carcinoma, squamous cell
  • Epidermoid carcinoma
  • Squamous cell skin cancer

What are the current treatments for Squamous Cell Skin Carcinoma?

Skin cancer generally has a high cure rate if it is treated early. Treatment depends on how big the tumor is, its location, and how far it has spread (metastasis). Methods of treatment for squamous cell carcinoma may include:
  • Curettage and desiccation - scraping away the cancer and using electricity to kill any remaining cancer cells; this is used to treat cancers that are not very large or deep
  • Surgical excision - cutting out of the tumor and stitching up the remaining tissue
  • Radiation therapy (if the skin cancer is located in an area difficult to treat surgically)
  • Microscopically controlled excision (Mohs surgery) - repeated cutting out of small pieces of tissue that are then examined microscopically to check if any cancer has been left behind; repeated application of this technique minimizes the removal of healthy tissue and is cosmetically more satisfying, especially if carried out with a plastic surgeon as part of the medical team. This is more likely to be used for skin cancers on the nose, ears, and other areas of the face.
  • Cryosurgery - freezing and killing the cancer cells
  • Skin creams and medications - may be used to treat superficial (not very deep) squamous cell carcinoma.

The outlook for small squamous cell lesions that are removed early and completely is extremely favorable, with about 95% cured if they are removed promptly.

Top Global Doctors For Squamous Cell Skin Carcinoma

Latest Advances On Squamous Cell Skin Carcinoma

  • Condition: Squamous Cell Carcinoma at the site of Ileo-Anal Pouch in Crohn's Disease
  • Journal: BMJ case reports
  • Treatment Used: Surgical Therapy and Chemoradiotherapy
  • Number of Patients: 1
  • Published —
This case report describes a patient with squamous cell carcinoma at the site of their ileo-anal pouch and Crohn's disease.
  • Condition: Non-Surgical Esophageal Squamous Cell Carcinoma
  • Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
  • Treatment Used: Raltitrexed Plus Cisplatin vs. Docetaxel Plus Cisplatin in Concurrent Chemoradiotherapy (CRT)
  • Number of Patients: 151
  • Published —
This study evaluated the effectiveness and toxicity of raltitrexed plus cisplatin versus docetaxel plus cisplatin in concurrent chemoradiotherapy (CRT) for the treatment of patients with non-surgical esophageal squamous cell carcinoma.

Clinical Trials For Squamous Cell Skin Carcinoma

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 64
  • Start Date: July 2021
Calcipotriol Plus 5-Flourouracil Immunotherapy for Skin Cancer Prevention in Organ Transplant Recipients
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug, Radiation, Other
  • Participants: 162
  • Start Date: July 2021
A Randomized, Blinded, Placebo Controlled Phase 2 Trial of Concurrent Radiation Therapy and Cisplatin With and Without BMX-001 in Patients With Locally Advanced Head and Neck Cancer