Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.
Several genetic changes have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. Most of these changes occur in genes that are involved in the normal function of the immune system.
SJS/TEN is a rare disease, affecting 1 to 2 per million people each year. Stevens-Johnson syndrome (the less severe form of the condition) is more common than toxic epidermal necrolysis.
SJS/TEN is not an inherited condition. However, the genetic changes that increase the risk of developing SJS/TEN can be passed from one generation to the next.
Charles Bouchard is an Ophthalmologist in Orland Park, Illinois. Bouchard has been practicing medicine for over 38 years and is rated as an Elite expert by MediFind in the treatment of Stevens-Johnson Syndrome. He is also highly rated in 28 other conditions, according to our data. His top areas of expertise are Stevens-Johnson Syndrome, Erythema Multiforme, Fuchs Dystrophy, Cataract Removal, and Corneal Transplant. Bouchard is currently accepting new patients.
James Chodosh is an Ophthalmologist in Boston, Massachusetts. Chodosh has been practicing medicine for over 35 years and is rated as an Elite expert by MediFind in the treatment of Stevens-Johnson Syndrome. He is also highly rated in 22 other conditions, according to our data. His top areas of expertise are Erythema Multiforme, Stevens-Johnson Syndrome, Interstitial Keratitis, Conjunctivitis (Pink Eye), and Corneal Transplant. Chodosh is currently accepting new patients.
Mayumi Ueta practices in Kyoto, Japan. Ueta is rated as an Elite expert by MediFind in the treatment of Stevens-Johnson Syndrome. She is also highly rated in 12 other conditions, according to our data. Her top areas of expertise are Stevens-Johnson Syndrome, Erythema Multiforme, Scalded Skin Syndrome, and Conjunctivitis (Pink Eye).
Summary: The NATIENS study is a phase III randomized study to examine the optimal treatment and mechanisms of each of two treatments (cyclosporine 5 mg/kg bid for 14 days versus etanercept 50 mg subcutaneously at day 0 and day 3) versus the current standard of care which is harmonized supportive care for the treatment of Stevens-Johnson Syndrome and toxic epidermal necrolysis (SJS/TEN). SJS/TEN is typicall...
Summary: A phase IIa, open label, non controlled clinical trial to assess the feasibility and safety of allogeneic adipose-derived mesenchymal stem cells (ASC) in the treatment of cicatricial conjunctivitis associated with Lyell's syndrome, Stevens-Johnson's syndrome and mucous membrane pemphigoid with ocular involvement
Published Date: January 01, 2020Published By: National Institutes of Health