Effect of Two Different Doses of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery , A Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Dexmedetomidine is a selective a-2 adrenergic agonist that provides sedative and analgesic effects. Intranasal dexmedetomidine has a slower and gradual onset compared to intravenous injection , with low incidence of nasal discomfort. Dexmedetomidine was tested at various doses and modes of administration, as well as different types of surgery and co-anesthetic drugs, as a single injection or continuous infusion. The authors have not agreed on the ideal clinical dose. The hypothesis is that intranasal dexmedetomidine 3mcg /kg will decrease the incidence of emergence agitation after strabismus surgery than dexmedetomidine 2 mcg/kg
Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 6
Healthy Volunteers: f
View:
• Age: 3-6 years, both sexes
• ASA physical status class I , II.
Locations
Other Locations
Egypt
Alexandria University
RECRUITING
Alexandria
Contact Information
Primary
sarah m elgamal, MD
sarahelgamal1990@yahoo.com
01005496440
Time Frame
Start Date: 2026-03-01
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 120
Treatments
Other: high dex group
patients will receive 3 mcg/kg intranasal dexmedetomidine 45minutes before surgery
Other: low dex group
patients will receive 2 mcg/kg intranasal dexmedetomidine 45minutes before surgery
Related Therapeutic Areas
Sponsors
Leads: Alexandria University