Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness in Patients With Hemorrhagic Stroke: A Pilot Study
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke. Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury Intervention: 30 ml cerebrolysin + 70 ml normal saline, days 4-17, once/day, intravenously or 100 ml normal saline, days 4-17, once/day, IV Comparison: cerebrolysin group versus control group Outcome: Coma Recovery Scale-revised, FDG-PET signal
• Patients with hemorrhagic stroke confirmed by CT or MRI
• Patients who have been in disorders of consciousness for more than 4 weeks after the onset of hemorrhagic stroke
• Patients in a vegetative state or minimally conscious state (Coma Recovery Scale -revised: CRS-R assessment)
• Age: 19 to 80 years of age
• Patients who have voluntarily given written informed consent to participate in the study by themselves or their legal representative.