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An Exploratory Study: The Effects of Cortical Priming on Visuomotor Stepping Learning in Healthy Adults and Persons With Chronic Stroke

Status: Recruiting

Location: See location...

Intervention Type: Combination product

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 21

Maximum Age: 90

Healthy Volunteers: t

View:

• Age between 21 and 90 years

• Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment

• MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract

• Hemiparesis involving the lower extremity (Fulg-Meyer LE motor test)

• No passive range of motion limitation in bilateral hips and knees

• Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less

• Visual acuity can be corrected by glasses or contact lens to 20/20

• Able to walk independently with/without assistant devices for 10 meters

• Able to maintain standing position without any assistance \> 30 sec (Short Physical Performance Battery)

⁃ Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24

Locations

United States

Texas

Physical Therapy, University of Texas Medical Branch

RECRUITING

Galveston

Contact Information

Primary

Shih-Chiao Tseng, PT, PhD

shtseng@utmb.edu

409--772-9555

Time Frame

Start Date: 2025-04-23

Estimated Completion Date: 2026-10

Participants

Target number of participants: 108

Treatments

Experimental: Explore the effects of brain stimulation on locomotor skill learning in stroke survivors

To explore the trends of locomotor skill learning in three groups: stroke survivors after five sessions of anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after five sessions of sham tDCS (s-tDCS), and stroke survivors with no brain stimulation (control; CON).

Experimental: determine the effects of a-tDCS on the cortical excitation before and after locomotor learning

measure changes in cortical neuronal activation before and after five sessions of locomotor skill training in healthy adults and stroke participants.

Experimental: To explore improvements in learning capacity between healthy adults and stroke participants.

Compare stimulation-induced improvements in learning capacity between three groups: stroke group, healthy young group, and healthy older group.

Experimental: To explore the trends of functional improvements after five tDCS session in stroke survivors

Compare functional improvements (gait performance, balance, motor and cognitive function) between healthy adults and stroke participants after five sessions of brain stimulation.

Related Therapeutic Areas

Stroke

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