Development of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined With Machine-assisted Bimanual Therapy (BT) in Upper Limb Rehabilitation
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are: * Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods? * Are changes in brain activity associated with improvements in upper limb function? Participants will be randomly assigned to different groups and will: * Receive rTMS stimulation on specific areas of the brain to modulate neural activity, * Perform machine-assisted bimanual exercises to promote motor skills, and * Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.
• Age 40-80 years;
• First-onset stroke patients;
• Patients diagnosed with cerebral infarction or hemorrhage through CT or MRI;
• Signed informed consent form by the patient and their family;
• Stable physiological parameters;
• Stroke occurred within the last 12 months;
• Patients with unilateral hand function impairment caused by the stroke;
• Upper limb muscle tone (Modified Ashworth Scale, MAS) less than 3 points;
• Able to follow two-step commands.