Brain-Computer Interface (BCI) With Virtual Reality (VR) in Upper Limb Rehabilitation After Stroke: A Randomized Crossover Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to investigate if training sessions of motor imagery associated with brain-computer interface and motor observation through virtual reality (MI-VR-BCI) can help to improve arm and hand recovery after a stroke. The main questions to answer are: * Can adding MI-BCI-VR sessions improve upper limb movement? * Can it help stroke survivors perform daily activities more easily? * Does this type of training improve brain activity and connections related to movement? Researchers will compare this type of intervention with motor imagery associated with a standard brain-computer interface intervention (MI-BCI) to see if there are added effects to upper limb function, activity and brain connections. Participants will : * Perform two intervention periods in a random order: one with MI-VR-BCI training sessions and other with MI-BCI training sessions. Each period will involve 3 weekly sessions of training, during 6 weeks, with the intervention periods being separated by 3 weeks. * Complete four assessment sessions: one at the beginning and another at the end of each intervention period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Clinical diagnosis of stroke confirmed by neuroimaging, with resulting upper limb hemiparesis.

• Time since stroke between 6 and 24 months at the time of selection.

• Sufficient cognitive ability to understand and follow the intervention procedures.

• Spasticity score \<3 on the Modified Ashworth Scale in upper limb muscle groups.

• Adults aged 18 to 80 years.

• Ability to remain seated for approximately 2 hours.

• Motivation to participate and capacity to provide informed consent.

• Undergoing conventional rehabilitation therapy during the study period.

Locations
Other Locations
Portugal
Centro de Medicina de Reabilitação de Alcoitão
RECRUITING
Alcabideche
Contact Information
Primary
Athanasios Vourvopoulos, PhD
athanasios.vourvopoulos@tecnico.ulisboa.pt
+351218418289
Time Frame
Start Date: 2026-01-05
Estimated Completion Date: 2027-03
Participants
Target number of participants: 12
Treatments
Experimental: MI-VR-BCI Training
Participants will perform motor imagery-based brain-computer interface training combined with immersive virtual reality and multimodal feedback (visual, auditory, and haptic).
Active_comparator: MI-BCI
Participants will perform motor imagery-based brain-computer interface (MI-BCI) training based on a cue-based protocol.
Related Therapeutic Areas
Sponsors
Collaborators: Centro de Medicina de Reabilitação de Alcoitão
Leads: Technical University of Lisbon

This content was sourced from clinicaltrials.gov