Efficacy of High-Frequency Repetitive Transcranial Magnetic Stimulation in Patients With Post-Stroke Cognitive Impairment: A Randomized Controlled Trial
To clarify the clinical efficacy of high-frequency rTMS on patients with post-stroke cognitive impairment, fNIRS and EEG techniques were used to observe the changes in brain functional activities of patients with post-stroke cognitive impairment after rTMS treatment, and to clarify the neuroregulatory effect of rTMS on patients with post-stroke cognitive impairment.
• Meets the diagnostic criteria for stroke as stipulated in the Guidelines for the Prevention and Treatment of Stroke in China (2021 Edition), and the initial stroke diagnosis is confirmed by cranial CT or MRI examination, and is confirmed as the initial onset;
• The disease course is 1-12 months;
• Has cognitive impairment (MoCA \< 26 points, education years ≤ 12 years, add 1 point to the score result);
• Age 35-75 years old, gender not limited;
• Stable vital signs, no progressive neurological symptoms;
• No severe aphasia, visual or auditory impairment, and able to complete the research protocol;
• Not using antidepressant drugs simultaneously;
• If using cognitive-improving drugs (such as donepezil, memantine), it should last for at least 3 weeks or more, and no dose adjustment will be made during the enrollment period;
• Voluntarily participate and sign the informed consent form.