Subacute Sclerosing PanencephalitisSymptoms, Doctors, Treatments, Advances & More
Learn About Subacute Sclerosing Panencephalitis
Subacute sclerosing panencephalitis (SSPE) is a progressive, disabling, and deadly brain disorder related to measles (rubeola) infection.
The disease develops many years after the measles infection.
SSPE; Subacute sclerosing leukoencephalitis; Dawson encephalitis; Measles - SSPE; Rubeola - SSPE
Normally, the measles virus does not cause brain damage. However, an abnormal immune response to measles or, possibly, certain variant forms of the virus may cause severe illness and death. This response leads to brain inflammation (swelling and irritation) that may last for years.
SSPE has been reported in all parts of the world, but in western countries it is a rare disease.
Very few cases are seen in the United States since the nationwide measles vaccination program began. SSPE tends to occur several years after a person has measles, even though the person seems to have fully recovered from the illness. Males are more often affected than females. The disease generally occurs in children and adolescents.
Symptoms of SSPE occur in four general stages. With each stage, the symptoms are worse than the stage before:
- Stage I: There may be personality changes, mood swings, or depression. Fever and headache may also be present. This stage may last up to 6 months.
- Stage II: There may be uncontrolled movement problems including jerking and muscle spasms. Other symptoms that may occur in this stage are loss of vision, dementia, and seizures.
- Stage III: Jerking movements are replaced by writhing (twisting) movements and rigidity. Death may occur from complications.
- Stage IV: Areas of the brain that regulate breathing, heart rate, and blood pressure are damaged. This leads to coma and then death.
There is no cure for SSPE. Treatment is generally aimed at regulating symptoms. Certain antiviral medicines and medicines that boost the immune system may be tried to slow the progression of the disease.
Atrium Health Levine Children's Neurology
Daniel Bonthius is a Pediatrics specialist and a Pediatric Neurologist practicing medicine in Charlotte, North Carolina. Dr. Bonthius is rated as an Advanced provider by MediFind in the treatment of Subacute Sclerosing Panencephalitis. He is also highly rated in 3 other conditions, according to our data. His clinical expertise encompasses Cerebellar Hypoplasia, Subacute Sclerosing Panencephalitis, Fetal Alcohol Syndrome (FAS), and Myoclonic Epilepsy. Dr. Bonthius is board certified in American Board Of Pediatrics. Dr. Bonthius is currently accepting new patients.
Divyani Garg practices practicing medicine in New Delhi, India. Garg is rated as an Elite expert by MediFind in the treatment of Subacute Sclerosing Panencephalitis. They are also highly rated in 49 other conditions, according to our data. Their clinical expertise encompasses Subacute Sclerosing Panencephalitis, Drug Induced Dyskinesia, Movement Disorders, Encephalitis, and Deep Brain Stimulation.
Ravindra Garg-Kumar practices practicing medicine in Lucknow, India. Mr. Garg-Kumar is rated as an Elite expert by MediFind in the treatment of Subacute Sclerosing Panencephalitis. He is also highly rated in 44 other conditions, according to our data. His clinical expertise encompasses Subacute Sclerosing Panencephalitis, Disseminated Tuberculosis, Tuberculous Meningitis, and Bacterial Meningitis.
The following resources can provide more information on SSPE:
- National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov/health-information/disorders/encephalitis
- National Organization for Rare Disorders -- rarediseases.org/rare-diseases/subacute-sclerosing-panencephalitis/
SSPE is always fatal. People with this disease die 1 to 3 years after diagnosis. Some people may survive longer.
Contact your health care provider if your child has not completed their scheduled vaccines. The measles vaccine is included in the MMR vaccine.
Immunization against measles is the only known prevention for SSPE. The measles vaccine has been highly effective in reducing the number of affected children.
Measles immunization should be done according to the recommended American Academy of Pediatrics and Centers for Disease Control schedule. The measles vaccine cannot cause SSPE.
Summary: The clinical significance of pulmonary embolism (PE) limited to the subsegmental pulmonary arteries, so called isolated subsegmental pulmonary embolism (SSPE), remains controversial. Whether isolated SSPE represents true PE, a clinically more benign form of PE, a physiologic lung clearing process, or a false positive result (artifact) is currently unclear and hence, whether patients with isolated ...
Published Date: August 19, 2024
Published By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Gans HA. Measles. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 293.
Gershon AA. Measles virus (rubeola). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 160.