COAgulation Disorders in Ischaemic and Haemorrhagic Stroke

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

In this study the investigators will assess both procoagulant and anticoagulant pathways using thrombin generation and platelet function tests; as well as neuronal ischemia using cell free DNA in all patients presenting with ischaemic and haemorrhagic stroke (including aneurysmal subarachnoid haemorraghe). Also the cross-talk between inflammation and thrombosis, so-called thrombo-inflammation is further investigated. As such the investigators aim to characterise the patient's coagulation profile before administration of any treatment. By assessing these pathways the investigators strive to detect specific markers to predict vital and functional outcome at 3 months in these patients. Finally the investigators may provide new pathophysiological insights in the course of disease following these events that can possibly improve future therapeutic strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Presenting at the hospital with ischaemic stroke, haemorrhagic stroke, aneurysmal subarachnoid haemorrhage or any other type of non-traumatic, intracranial bleeding

• In patients with minor ischemic stroke (NIHSS \<= 4) only baseline lab sampling will be performed (T0 and T0B).

Locations
Other Locations
Belgium
Ziekenhuis Oost-Limburg
RECRUITING
Genk
Contact Information
Primary
Hendrik Stragier, MD
hendrik.stragier@zol.be
+3289325277
Time Frame
Start Date: 2023-05-02
Estimated Completion Date: 2025-08-31
Participants
Target number of participants: 350
Treatments
Ischemic Stroke
Patients presenting at emergency department / Intensive Care unit with ischemic stroke~* registration of baseline clinical data~* registration of baseline blood parameters (in context of standard of clinical care)~* additional blood sampling at 5 time points during 1st week with the purpose of full coagulation testing and cell free DNA methylation
Haemorrhagic stroke
Patients presenting at emergency department / Intensive Care unit with haemorraghic stroke (spontaneous intracranial bleeding, no trauma)~* registration of baseline clinical data~* registration of baseline blood parameters (in context of standard of clinical care)~* additional blood sampling at 5 time points during 1st week with the purpose of full coagulation testing and cell free DNA methylation
Aneursmal Subarachnoid Haemorrhage
Patients presenting at emergency department / Intensive Care unit with aneurysmal subarachnoid haemorrhage~* registration of baseline clinical data~* registration of baseline blood parameters (in context of standard of clinical care)~* additional blood sampling at 5 time points during 1st week with the purpose of full coagulation testing and cell free DNA methylation
Related Therapeutic Areas
Sponsors
Collaborators: Synapse bv
Leads: Ziekenhuis Oost-Limburg

This content was sourced from clinicaltrials.gov