Cortical Activation and Functional Connectivity Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared spectroscopy (fNIRS). The main questions it aims to answer are: * The alteration of cortical activation during swallowing in patients with LMS compared with healthy subjects. * The alteration of cortical functional connectivity during swallowing in patients with LMS compared with healthy subjects. fNIRS will be used to detect cortical activation and functional connectivity during swallowing tasks in LMS patients and healthy subjects, and to compare the differences between patients and healthy subjects.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• The first ischemic stroke was confirmed by head MRI as LMS;

• 18-80 years old, right-handed;

• Dysphagia was confirmed by video fluoroscopic swallow study(VFSS);

• Conscious enough to cooperate with fNIRS testing;

• No previous neurological or mental illness.

Locations
Other Locations
China
The First Affiliated Hospital of Zhengzhou University
RECRUITING
Zhengzhou
Contact Information
Primary
Yi Li, Master
muziyi3696085@163.com
+8618810838848
Time Frame
Start Date: 2023-05-31
Estimated Completion Date: 2024-02-15
Participants
Target number of participants: 20
Treatments
LMS patients
The demographic characteristics will be collected, including sex, age, stroke duration, and lesion side; Penetration-aspiration (PAS) scale will be used to evaluate swallowing function. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
healthy subjects
The demographic characteristics will be collected, including sex and age. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
Related Therapeutic Areas
Sponsors
Leads: The First Affiliated Hospital of Zhengzhou University

This content was sourced from clinicaltrials.gov