Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis
Who is this study for? Patients with Syphilis, Human Immunodeficiency Virus
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
• 18 years of age or older
• Able to provide informed consent
• Individuals with HIV infection must be on treatment for HIV infection and virologically suppressed (viral load \<200 copies/mL) or have a CD4 count ≥ 350 cells/mm3 according to most recent labs before study enrollment
Locations
United States
California
University of Southern California
RECRUITING
Los Angeles
Contact Information
Primary
Jeffrey D Klausner
jdklausner@med.usc.edu
(415) 876-8901
Time Frame
Start Date: 2021-06-20
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 400
Treatments
Experimental: Cefixime
Oral cefixime 400mg, taken twice a day for 10 days
Active_comparator: Benzathine Penicillin G
Single intramuscular injection of 2.4 million units of benzathine penicillin G
Sponsors
Leads: University of Southern California
Collaborators: AIDS Healthcare Foundation, Universidad Peruana Cayetano Heredia