Systemic Capillary Leak Syndrome Overview

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Learn About Systemic Capillary Leak Syndrome

What is the definition of Systemic Capillary Leak Syndrome?
Systemic capillary leak syndrome (SCLS) causes fluid and proteins to leak out of tiny blood vessels (capillaries) into surrounding tissues. This may lead to very low blood pressure (hypotension), hypoalbuminemia, and thickened blood due to a decrease in plasma volume (hemoconcentration). Initial symptoms may include tiredness, nausea, abdominal pain, extreme thirst, and sudden increase in body weight. Complications can include general swelling, compartment syndrome, kidney failure, and stroke. SCLS occurs in episodes which vary in frequency, with some people having one episode in their lifetime, and others having several per year. The severity also varies, and the condition can be fatal. In many cases, the cause is not known (idiopathic SCLS). Diagnosis is based on the symptoms, clinical examination and other laboratory tests.
What are the alternative names for Systemic Capillary Leak Syndrome?
  • Systemic capillary leak syndrome
  • Capillary leak syndrome
  • Capillary leak syndrome with monoclonal gammopathy
  • Clarkson disease
  • Periodic systemic capillary leak syndrome
  • SCLS
Who are the top Systemic Capillary Leak Syndrome Local Doctors?
Elite in Systemic Capillary Leak Syndrome
Maddalena A. Wu
Elite in Systemic Capillary Leak Syndrome
Maddalena A. Wu
Milan, IT 

Maddalena Wu practices in Milan, Italy. Ms. Wu is rated as an Elite expert by MediFind in the treatment of Systemic Capillary Leak Syndrome. Her top areas of expertise are Systemic Capillary Leak Syndrome, Angioedema, Hives, and Hereditary Angioedema.

Elite in Systemic Capillary Leak Syndrome
Marc Chambrun-De
Elite in Systemic Capillary Leak Syndrome
Marc Chambrun-De
Paris, FR 

Marc Chambrun-De practices in Paris, France. Mr. Chambrun-De is rated as an Elite expert by MediFind in the treatment of Systemic Capillary Leak Syndrome. His top areas of expertise are Systemic Capillary Leak Syndrome, Cardiogenic Shock, Antiphospholipid Syndrome, Heart Transplant, and Lung Transplant.

 
 
 
 
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Nikolajs Lapins
Distinguished in Systemic Capillary Leak Syndrome
Dr. Nikolajs Lapins
Dermatology
Distinguished in Systemic Capillary Leak Syndrome
Dr. Nikolajs Lapins
Dermatology
Burlingame, CA 
650-692-0182
Languages Spoken:
English
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Accepting New Patients

Nikolajs Lapins is a Dermatologist in Burlingame, California. Dr. Lapins is rated as a Distinguished provider by MediFind in the treatment of Systemic Capillary Leak Syndrome. His top areas of expertise are Systemic Capillary Leak Syndrome, Liver Spots, Universal Acquired Melanosis, and Squamous Cell Skin Carcinoma. Dr. Lapins is currently accepting new patients.

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What are the latest Systemic Capillary Leak Syndrome Clinical Trials?
Evaluation of the Levels of O-GlcNAcylation of Cardiac and Blood Proteins in Paediatric Cardiac Surgery and Identification of Therapeutic Targets
Evaluation of the Levels of O-GlcNAcylation of Cardiac and Blood Proteins in Paediatric Cardiac Surgery and Identification of Therapeutic Targets
Enrollment Status: Recruiting
Publish Date: April 13, 2025

Summary: Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal circuitry to patient size make younger and smaller patients more vulnerable to organ injury. The main problem associated with ECC in neonates and infants is the duration of ECC d...

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Phase II Randomized Study Evaluating a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer
Phase II Randomized Study Evaluating a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer
Enrollment Status: Recruiting
Publish Date: January 28, 2025
Intervention Type: Biological
Study Phase: Phase 2

Background: The presence of T-lymphocytes in resected tumor samples derived from long-term survival patients and the fact that reinvigoration of their functionality through the administration of specific immune-therapies can lead to remarkable antitumor responses supports that lymphocytes play a critical role in cancer immunity. TIL-based ACT (Adoptive cell therapy using tumor-infiltrating lymphocytes product...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center