Condition 101 About Tetralogy of Fallot

What is the definition of Tetralogy of Fallot?

Tetralogy of Fallot is a complex congenital heart defect characterized by a large ventricular septal defect (hole between the right and left ventricles), pulmonary stenosis (narrowing of the valve and artery that connect the heart with the lungs), an overriding aorta (the aorta - the artery that carries oxygen-rich blood to the body - is shifted over the right ventricle and ventricular septal defect, instead of coming out only from the left ventricle), and right ventricular hypertrophy (the muscle of the right ventricle is thicker than usual). Tetralogy of Fallot causes low oxygen levels in the blood, which can lead to cyanosis (a bluish-purple color to the skin). The cause of this condition is unknown. Treatment involves surgery to repair the heart defects. Sometimes more than one surgery is needed. 

What are the alternative names for Tetralogy of Fallot?

  • TOF
  • Fallot tetralogy

Latest Advances On Tetralogy of Fallot

  • Condition: Neonates With Symptomatic Tetralogy of Fallot (sTOF)
  • Journal: Journal of the American College of Cardiology
  • Treatment Used: Staged Repair (SR) vs. Primary Repair (PR)
  • Number of Patients: 342
  • Published —
This study compared staged repair (SR) versus primary repair (PR) in the treatment of neonates with symptomatic tetralogy of Fallot (congenital heart defect; sTOF).
  • Condition: Enlarged Native Right Ventricular Outflow Tract (RVOT)
  • Journal: Anatolian journal of cardiology
  • Treatment Used: Edwards SAPIEN XT and SAPIEN 3 Valves
  • Number of Patients: 129
  • Published —
This study tested the safety and efficacy of using Edwards SAPIEN XT and SAPIEN 3 valves to treat patients with enlarged native RVOT.

Clinical Trials For Tetralogy of Fallot

Clinical Trial
  • Status: Recruiting
  • Phase: Phase 1
  • Intervention Type: Other, Procedure, Drug
  • Participants: 40
  • Start Date: February 2021
Mechanistic Clinical Trial of Beta-Blocker Administration For Reactivating Cardiomyocyte Division In Tetrology of Fallot
Clinical Trial
  • Status: Recruiting
  • Intervention Type: Procedure
  • Participants: 100
  • Start Date: January 1, 2020
Prospective Evaluation of Programmed Ventricular Stimulation Before Pulmonary Valve Replacement in Patients With Tetralogy of Fallot