Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 20
Healthy Volunteers: f
View:

• Patients undergoing cardiopulmonary bypass surgery

• Patients undergoing surgery for repair of congenital heart disease such as ventricular septal defect or defective mitral or aortic valves.

Locations
United States
Georgia
Emory University School of Medicine
RECRUITING
Atlanta
Contact Information
Primary
Michael E Davis, PhD
medavis@emory.edu
404-727-9858
Backup
Kati Miller
kati.miller@choa.org
404-729-0492
Time Frame
Start Date: 2005-04
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 600
Treatments
Cardiac Tissue
Cardiac tissue and cells will be obtained from participants undergoing cardiac surgical repair
Related Therapeutic Areas
Sponsors
Leads: Emory University
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)

This content was sourced from clinicaltrials.gov